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Abstract Details

Bariatric Berberi; The Other Thiamine Deficiency
General Neurology
General Neurology Posters (7:00 AM-5:00 PM)
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The CDC reports the prevalence of obesity in the US as 42.4% in 2017 – 2018. Thus, Americans have turned to surgical interventions in order to combat obesity. Per the American Society for Metabolic and Bariatric Surgery, 252,000 bariatric surgeries were performed in 2018. Surprisingly, 20-30% of patients have micronutrient deficiencies preceding surgery and the prevalence of post-surgical neurologic complications secondary to nutritional deficiencies range from 1.3 – 16%. The below case highlights under-recognized neurologic complications secondary to nutritional complications from bariatric surgery.

62-year-old woman with history of obesity presented four months post Roux-en-Y anastomosis with progressive ascending paresthesia of the lower extremities, paraparesis, and radicular pain. Post-surgical course was notable for protracted nausea and vomiting requiring recurrent hospitalizations for intravenous (IV) hydration. Examination demonstrated a large and small fiber polyneuropathy in all four extremities and a mild symmetric paraparesis. Subsequent work-up was notable for a thiamine level of 38.1 nmol/L. The patient was diagnosed with dry beriberi and admitted for IV thiamine supplementation. Treatment with thiamine 500mg three time daily for three days followed by 100mg oral supplementation daily thereafter was initiated. The patient’s neuropathic pain and sensory abnormalities improved, however she never returned to her premorbid baseline.

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Physiologic/anatomic changes following bariatric surgery increases patients’ risk for developing metabolic neurologic disorders. Low body stores and a short half-life make thiamine deficiency an all too common complication. Dry beriberi is an important complication of thiamine deficiency to recognize, like Wernicke ’s Encephalopathy, it requires early recognition and aggressive treatment to prevent permanent complications. Dry beriberi is a polyneuritis characterized by muscle weakness, pain, and paralysis. Clinically, dry beriberi can mimic Guillian-Barre syndrome with ascending sensory deficits and weakness. Neurologists need to maintain a high clinical suspicion for thiamine deficiency disorders in those who have undergone bariatric surgery.  
Authors/Disclosures
Michael B. Beeler, DO
PRESENTER
Dr. Beeler has received personal compensation for serving as an employee of United States Navy.
Steven M. McKnight, MD Steven M. McKnight has nothing to disclose.