Abstract Details

Title Hereditary hemorrhagic telangiectasia and pulmonary and cerebral complications: A case report and literature review

Topic General Neurology

Presentation(s) General Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 027

Objective This study explores a patient case of Hereditary Hemorrhagic Telangiectasia (HHT) leading to silent pulmonary arteriovenous malformation (AVM) leading to brain abscess, highlighting the significance of early screening in patients with symptoms suspicious of HHT.

Background HHT is an autosomal dominant disorder characterized by abnormal vascular growths leading to AVM in various organs. Pulmonary AVM is a common presentation of HHT which can result into pulmonary arteriovenous fistula leading to neurologic complications such as brain abscess and meningitis. We report a case of silent pulmonary AVM leading to brain abscess in a previously undiagnosed HHT patient.

Design/Methods This is a case of a pulmonary AVM and concomitant frontoparietal brain abscess in a 48-year-old female with HHT treated with antibiotics and wedge resection.

Results A 48-year-old female with chronic epistaxis presents with a subacute headache and right leg weakness. Familial history was suspicious for HHT with the imaging findings. CT Chest revealed a left lower lung AVM with growing thrombus and brain MRI showed a large frontoparietal brain abscess. The brain abscess was treated with antibiotics and the pulmonary AVM surgically managed with wedge resection. The patient made a gradual complete neurological recovery after initiation of appropriate antibiotics.

Conclusions The patient above had chronic recurrent epistaxis but otherwise a silent pulmonary AVM leading to brain abscess and therefore, presentation of neurologic symptoms. In conclusion, this case illustrates the significance of screening for pulmonary AVM in patients with HHT suggestive symptoms to prevent further neurological sequelae. Neurologists and emergency physicians should be wary that HHT patients may also present initially with neurological symptoms secondary to brain abscess due to silent pulmonary AVM.

Authors/Disclosures
Ah Ryung Lim PRESENTER	Miss Lim has nothing to disclose.
	No disclosure on file
	No disclosure on file
Eu Jene Choi, MD, PhD(c)	Dr. Choi has nothing to disclose.

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