Abstract Details

Title Neurologic Manifestations in Polycythemia; A 5 Year Study from South India

Topic General Neurology

Presentation(s) General Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 023

Objective

To describe and analyze the neurologic manifestations in patients with polycythemia.

Background Clinical manifestations in polycythemia, arising from hyperviscosity or otherwise, are varied and include an array of neurologic features. Though commonly encountered clinically, no studies have analyzed neurologic manifestations in the Indian context. We investigated the neurological signs and symptoms in patients with polycythemia.

Design/Methods We conducted a cross-sectional study of adults diagnosed with polycythemia between 2014 and 2018 at a tertiary care center of South India. We excluded patients with relative polycythemia or any neurologic disease prior to the diagnosis of polycythemia. We collected relevant medical data with special focus on neurologic manifestations, either as presenting complaints or associated features. We later performed descriptive analyses, and inferential analyses with regards to comorbidities, the degree and the type of polycythemia. We also performed a subgroup analysis of patients with polycythemia vera.

Results We analyzed data from 192 patients with polycythemia. 119 patients (61.66%) had symptoms referable to the nervous system. The most common was cerebrovascular disease – (n=59; 30.73%), followed by headache (n 38; 19.79%), peripheral neuropathy, seizures, dizziness, visual symptoms, papilledema, extrapyramidal symptoms, and tinnitus. There was no significant difference in the presence of neurological manifestations among patients with polycythemia vera vs other causes of polycythemia. The degree of hematocrit increase did not appear to influence the clinical presentation.

Conclusions Neurologists must be aware that neurologic manifestations are common in patients with polycythemia due to any cause. The most common manifestation in our study was cerebrovascular disease, followed by headache.

Authors/Disclosures
Vivek Bhat PRESENTER	Mr. Bhat has nothing to disclose.
	No disclosure on file
	No disclosure on file

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