Objective: Determine cranial nerves affected, combination of compromised cranial nerves, causes and the site of injury in patients with the diagnosis of multiple cranial neuropathies (MCN).

Background. Multiple cranial neuropathies (MCN) can result from a vast range of etiologies, localized anywhere from the brainstem to the peripheral nerves. The approach of these patients can be challenging. There is a insufficient description about this entity in the clinical practice and to our knowledge, the largest published case series of MCN is composed by 979 patients and ours would be the second largest case series to date.

Methodology: Retrospective case series. Patients who met the diagnosis criteria of MCN from 2014 to 2020 in a Hospital in Bogotá-Colombia were included.

Results: 130 patients were collected during the 2014-2020 period. The cranial nerves most commonly affected in order of frequency were: III, VII, IX, VI and V. The most frequent combinations of cranial nerve involvement were: III-VI, III-IV, V-VII, III-VII and IX-X-XII. The most frequent causes were autoimmune, vascular, neoplastic, infectious, and idiopathic. Lastly, the most frequent locations of the lesions were peripheral nerve, neuromuscular junction, cavernous sinus, medulla and midbrain.

Conclusion: MCN is a very diverse syndrome, its diagnosis is based on clinical findings in relation to the topography of the lesions and the associated etiology, elements necessary to obtain a more precise diagnosis.