Abstract Details

Title Coronavirus Disease 2019 in Patients With Prior Ischemic Stroke

Topic General Neurology

Presentation(s) General Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 012

Objective A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in December 2019 and soon led to a worldwide pandemic, coronavirus disease 2019 (COVID-19). COVID-19 has been shown to cause several neurological manifestations including ischemic strokes. Stroke is one of the chronic diseases with very high morbidity and mortality causing a huge financial burden to the healthcare economy. The purpose of this study is to explore if patients with prior ischemic stroke are a vulnerable population for worse clinical outcomes in patients with COVID-19.

Background It is uncertain if patients with prior ischemic stroke are vulnerable to coronavirus
disease 2019 (COVID-19) and its complications.

Design/Methods We used TriNetX, a global health collaborative clinical research platform with a large
global COVID-19 database. COVID-19 infection was identified with a positive lab value for
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related ribonucleic acid
(RNA).

Results A total of 604,258 patients with history of ischemic stroke were identified, of which
891 patients (study cohort) were diagnosed with COVID-19. A control cohort with 32,136
patients diagnosed with COVID-19 after January 20th 2020 without a history of ischemic stroke
were identified. A comparison between study cohort and control cohort showed patients with
prior history of stroke (study cohort) were older (69.5 vs 47.8; p<0.0001) and had more
comorbidities contributing to worse clinical outcomes. After propensity matching for
demographic variables and comorbidities, only rate of hospitalization (287 vs 231; p=0.0035)
and need for critical care services (85 vs 55; p=0.0082) remained statistically significant while
intubation (51 vs 43; p=0.39) and death (119 vs 115; p=0.77) showed trends towards worse
outcomes but were not statistically significant

Conclusions Patients with history of ischemic stroke tend to be significantly older with
several comorbid conditions contributing to worse clinical outcomes after COVID-19, which
makes them a vulnerable population.

Authors/Disclosures
Carolina Gil Tommee, MD PRESENTER	Dr. Gil Tommee has nothing to disclose.
Krishna Nalleballe, MD, FAAN	Dr. Nalleballe has nothing to disclose.
Suman Siddamreddy	Suman Siddamreddy has nothing to disclose.
Sen Sheng, MD	Dr. Sheng has nothing to disclose.
Vasuki Dandu, MD (Baptist health)	Dr. Dandu has nothing to disclose.
Narenraj Arulprakash, MD (Baptist Health)	Dr. Arulprakash has nothing to disclose.
Sukanthi Kovvuru, MD (University of Arkansas Medical Sciences)	Dr. Kovvuru has nothing to disclose.
	No disclosure on file
Madhu S. Jasti, MD, FAAN	Dr. Jasti has nothing to disclose.
Sanjeeva R. Onteddu, MD, FAAN (UMass Medical School)	Dr. Onteddu has nothing to disclose.

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