To report the safety and tolerability of at-home remotely supervised transcranial direct current stimulation (RS-tDCS), including when paired with rehabilitation and extended periods of repeated administration.

tDCS is a noninvasive brain stimulation technique investigated for a wide range of behavioral and clinical applications including to enhance rehabilitative outcomes. tDCS requires repeated daily administration for cumulative behavioral effects and clinical benefit. We developed a telehealth protocol, remotely supervised, for at-home access for daily repeated treatments.

Analyses included n=7,239 at-home RS-tDCS sessions from n=351 participants with neurological conditions. Participants were 18-78 years old and included also those with severe levels of neurologic disabilities. There were no serious AEs. None of the participants reporting pain greater than 7 during the study were discontinued, and session-limiting AEs were rare (27 events/0.004%). Most frequent reported AEs (active/sham) were tingling (61%/73%), followed by warmth sensation (38%/38%), and itching (34%/41%) and were not treatment-limiting. AEs frequency did not significantly change across repeated daily exposures (p>0.050). There was 96% completion rate of protocols administering >20 sessions of tDCS.