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Abstract Details

Do Neurological Manifestations Following SARS-CoV-2 Infection Beget A Poor Prognosis?
Infectious Disease
S18 - COVID-19: From Bedside and Beyond (2:48 PM-3:00 PM)
010
Investigate the effect of neurological manifestations on the prognosis of SARS-CoV-2 infection.

Mounting evidence suggests that neurological manifestations of SARS-CoV-2 infection are associated with a severe prognosis.
Using medical records from University Hospital, Newark NJ, we investigated the outcomes of patients regarding their COVID-19 and neurological status. The groups included patients with COVID-19 and with neurological manifestations (COVID-19N), without COVID-19 and with neurological manifestations (non COVID-19N), with COVID-19 and without neurological manifestations (COVID-19WN), and without COVID-19 or neurological diagnosis (NCOVID-19WN). 
Among the 1,356 COVID-19 and 37,111 non COVID-19 patients, 25.3% vs 19.5% developed neurological complications, respectively. The average length of stay (LoS) in days and mortality were significantly higher in COVID-19N compared to non COVID-19N, COVID-19WN, and NCOVID-19WN respectively (12; 45.2% vs 10; 9.8% vs 7; 13.2% vs 5; 1.3% p<0.05). The proportion of patients admitted to the ICU was significantly highest in non COVID-19N compared to COVID-19N, COVID-19WN, and NCOVID-1WN respectively (36.4% vs. 31.5% vs. 10% vs. 16.6% p<0.05).  The ICU LoS in days was significantly higher in COVID-19N compared to non COVID-19N, COVID-19WN, NCOVID-1WN respectively (11 vs. 5 vs. 7 vs. 3 p<0.05). The rate of home discharge was significantly lower in the COVID-19N compared to non-COVID-19N and to COVID-19WN and NCOVID-19WN respectively (41.5% vs. 48.8% vs. 75.1%, VS 78.6% p<0.001). The rate of discharge to hospice was significantly higher in the COVID-19N compared to non-COVID-19N and COVID-19WN and NCOVID-19WN (5.3% vs. 2.4% vs. 0.6% vs. 0.8% p<0.05). The rate  of discharge to skilled nursing facilities was significantly higher in the COVID-19N compared to non-COVID-19N and COVID-19WN and NCOVD-19WN (34.0% vs 23.9% vs 9.8% vs 8.6% p<0.05).
Our study demonstrated that neurological manifestations of SARS-CoV-2 infection are associated with significant increase in death rate, length of hospitalization including length of stay in ICU and hospice discharges.
Authors/Disclosures

PRESENTER 		No disclosure on file
Kranthi K. Mandava Mr. Mandava has nothing to disclose.
Mustafa Jaffry Mr. Jaffry has nothing to disclose.
Mohsen Ahmed (New Jersey Medical school) Mr. Ahmed has nothing to disclose.
Kazim Jaffry Mr. Jaffry has nothing to disclose.
Nizar Souayah, MD, FAAN (NJMS) Dr. Souayah has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. Dr. Souayah has received publishing royalties from a publication relating to health care.