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Abstract Details

Figure-Ground Testing as an Accurate and Efficient Tool For Clinical Screening of Posterior Cortical Atrophy
Aging, Dementia, and Behavioral Neurology
P14 - Poster Session 14 (11:45 AM-12:45 PM)
3-003
This study aimed to identify neurobehavioral screening tests for Posterior cortical atrophy (PCA), beyond simple visual constructions that can be administered in the clinic or at the bedside
Posterior cortical atrophy (PCA) is a progressive neurological syndrome that is characterized by early deficits in higher visual and parietal processing. Although PCA is a type of Alzheimer’s disease (AD), its diagnosis is commonly delayed due to lack of understanding on how to clinically screen for this syndrome, additionally delaying the development of early interventions.

This study included two groups. Group one was composed of patients who met neuroimaging-supported Consensus Criteria for PCA (n=12), and matched typical AD (tAD) patients (n=12). The other group were healthy controls (HC), who were matched with the patient group in terms of age and education (n=24). The participants underwent assessment for the following eight clinic/bedside tasks: (1) Balint’s syndrome, (2) visual object agnosia, (3) color recognition, (4) figure-ground discrimination, (5) global-local processing, (6) dressing “apraxia” or difficulty, (7) ideomotor apraxia, and (8) Gerstmann’s syndrome.
Figure-ground testing could successfully differentiate patients from the HC participants with an accuracy and sensitivity of 100%. About 50% of patients with PCA had Balint’s syndrome, dressing apraxia, or ideomotor apraxia compared to 0% in patients with tAD. The occurrence of global-local processing deficits or Gerstmann’s syndrome failed to distinguish patients across dementia groups.

The results show that figure-ground testing can be incorporated as an overall screening task for the presence of PCA, followed by specific examinations for Balint’s syndrome and dressing and limb apraxias. These findings further reinforce the concept of PCA as a predominant occipitoparietal disorder with dorsal visual stream involvement and parietal signs with spatiomotor impairments
Authors/Disclosures
Golnoush Akhlaghipour, MD
PRESENTER 		Dr. Akhlaghipour has nothing to disclose.
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.
No disclosure on file
Oleg Y. Yerstein, MD Dr. Yerstein has nothing to disclose.