Abstract Details

Title Social cognition and behavioral assessments improve the diagnosis of behavioral variant of frontotemporal dementia in older Peruvians with low educational levels

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-002

Objective We sought to evaluate the diagnostic accuracy of brief socio-cognitive and behavioral tests that may differentiate behavioral variant of frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) in patients with low educational levels.

Background bvFTD is characterized by early behavioral abnormalities and late memory impairment with a detrimental impact on patients and caregivers. bvFTD is difficult to distinguish from AD particularly in low educational levels. Combining brief socio-cognitive and behavioral evaluations with standard cognitive testing could better discriminate bvFTD from AD.

Design/Methods

We evaluated 51 individuals over age 50 with low educational levels and a diagnosis of bvFTD or AD from a multidisciplinary neurology clinic in Lima, Peru, between July 2017 and December 2020. All patients underwent a full neurocognitive battery and brief cognitive tests (Addenbrooke’s Cognitive Examination version III, ACE-III), social cognition (Mini-social Cognition and Emotional Assessment, Mini-SEA), and behavioral assessments (Frontal Behavioral Inventory, FBI; Interpersonal Reactivity Index—Emphatic Concern, IRI-EC; IRI—Perspective Taking, IRI-PT; and Self-Monitoring Scale—revised version, r-SMS). Receiver operating characteristic (ROC) analyses to calculate the area under the curve (AUC) were performed.

Results The AD group was significantly older than the bvFTD group (p<0.001). An analysis of the discriminatory ability of the ACE-III to distinguish between patients with AD and bvFTD (AUC = 0.85) and the INECO Frontal Screening (IFS; AUC = 0.78) shows that the former has greater discriminatory ability. Social and behavioral cognition tasks were able to appropriately discriminate bvFTD from AD. The FBI had high sensitivity (83%), and the IRI-EC and IRI-PT were adequate for differentiating between bvFTD and AD. The Mini-SEA had high sensitivity and high-moderate specificity for discriminating bvFTD from AD, which increased when combined with the ACE-III and IFS.

Conclusions Our study supports the integration of socio-behavioral measures to standard global cognitive and social cognition measures to screen for bvFTD in a population with low educational levels.

Authors/Disclosures
Nilton Custodio Capunay, MD, FAAN (Instituto Peruano De Neurociencias) PRESENTER	Dr. Custodio Capunay has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Maritza Pintado-Caipa, MD (Instituto Peruano de Neurociencias)	Dr. Pintado-Caipa has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Monica M. Diaz, MD, MS (University of North Carolina at Chapel Hill)	The institution of Dr. Diaz has received research support from CorEvitas. The institution of Dr. Diaz has received research support from Novartis. The institution of Dr. Diaz has received research support from Bodford Family Transverse Myelitis Center Fund.

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