Abstract Details

Title Autoimmune encephalitis in a tertiary hospital in the Philippines

Topic Autoimmune Neurology

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 9-006

Objective

To describe the clinical and paraclinical features, and treatment outcomes of patients with autoimmune encephalitis (AE) admitted in a Philippine tertiary hospital.

Background

AE is an emerging disorder in adults and children. Due to its potentially reversible nature, prompt recognition and intervention are of utmost importance.

Design/Methods

Retrospective case series of patients with definite AE.

Results Eighteen (18) patients were included (12 adults, 6 children), majority of whom had anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. The median age of onset was 32 (IQR: 27.25 - 38) years old and 13 (IQR: 10.25 - 15) years old in the adult and pediatric population, respectively. In both age groups, most presented with psychiatric symptoms and normal imaging findings. Cerebrospinal fluid (CSF) pleocytosis was detected in 8/12 (66.7%) adults and 2/6 (33.3%) children, while CSF protein elevation was only seen in 6/12 (50%) adults. Most patients presented with seizures, and the most frequent electroencephalography (EEG) abnormality seen was slow activity (70.5%). A high proportion of patients received high dose steroids, alone (35.3%) or in combination with intravenous immunoglobulin (IVIG, 52.9%). Overall, 66.7% had improved outcomes, mostly seen in the pediatric population.

Conclusions This study highlighted the broad clinical phenotype, as well as the similarities and differences of AE manifestations in adults and children. It demonstrated the limited but supportive role of laboratory investigations in the diagnosis of AE. It also underscored the importance of early intervention in AE and highlighted factors influencing treatment practices and discharge outcomes in the local setting.

Authors/Disclosures
Nikolai Gil D. Reyes, MD (University of Toronto - Toronto Western Hospital) PRESENTER	Dr. Reyes has nothing to disclose.
Adrian I. Espiritu, MD (Ontario Shores Centre for Mental Health Sciences)	Dr. Espiritu has nothing to disclose.
	No disclosure on file
Joshual E. Abejero	No disclosure on file
Rhea Angela Salonga, MD (Medical Center Manila)	Dr. Salonga has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medichem . Dr. Salonga has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Hi-Eisai . Dr. Salonga has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbott . Dr. Salonga has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Torrent Philippines. Dr. Salonga has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Philippine League Against Epilepsy.
Leonor Cabral-Lim, MD, FAAN (Department of Neurosciences UP-PGH Medical Center)	Dr. Cabral-Lim has received personal compensation in the range of $0-$499 for serving as a Consultant for Hi-Eisai Pharmaceuticals Inc., Philippines . Dr. Cabral-Lim has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Hi-Eisai Pharmaceutical Inc., Philippines . Dr. Cabral-Lim has received research support from UCB BIOPHARMA SPRL . Dr. Cabral-Lim has received personal compensation in the range of $500-$4,999 for serving as a Member, Philippine Council for Mental Health with Department of Health,Philippines .
Roland Dominic Jamora (Philippine General Hospital)	Roland Dominic Jamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for torrent. Roland Dominic Jamora has received research support from CCXDP.
	No disclosure on file
	No disclosure on file
Katerina Tanya P. Gosiengfiao	No disclosure on file

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