Abstract Details

Title Clinical Profile of Frontotemporal Dementia: Case Series from a Neurological Care Center in Peru

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 7-006

Objective To determine clinical features of patients affected with frontotemporal dementia (FTD) followed up at a Neurological healthcare center in Peru.

Background FTD is a clinical syndrome. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. The prevalence of FTD in Peru is estimated at 1.9%. There is limited information on clinical aspects of FTD in the Peruvian population.

Design/Methods

We reviewed clinical records of patients diagnosed with probable FTD over 2010-2020 using 2011 diagnostic criteria. Local IRB approval was obtained for this study.

Results We included 21 cases that fulfilled the selection criteria. Twelve cases (57.1%) were categorized as bvFTD, 8 cases (38.1%) nfvPPA, and 1 (4.8%) svPPA. There was slightly male predominance (57%). The average of education was 9.6±4.6 years. The two main regions of origin were Lima (6 cases) and Ancash-northern Peru (6 cases). We found 6.67±3.73 and 4.75±2.19 years of diagnostic delay for bvFTD and PPA, respectively. The mean age at onset for bvFTD and nfvPPA groups was 50.7±9.7, and 62.4±12.26 respectively. The first symptom identified in the bvFTD group was disinhibition 6 (50%), while nfvPPA was effortful, halting speech 6 (75%). The most frequent supportive symptoms for bvFTD were disinhibition and apathy 8 (66.7%). Dysexecutive dysfunction was present in 11 (91.7%) and loss of empathy 1(8.3%). nfvPPA group showed agrammatism in language production and effortful speech in 7 patients (87.5%), parkinsonism was present in 5 patients (62.5%).

Conclusions The main clinical features of the FTD reported are consistent with existing literature. Loss of empathy is not identified as a supporting symptom of bvFTD. Further studies are required to identify associated factors affecting the timely diagnosis of FTD in Peru.

Authors/Disclosures
Sheila C. Suarez, MD (Instituto Nacional De Ciencias Neurologicas) PRESENTER	Dr. Suarez has nothing to disclose.
Erik A. Guevara-Silva, MD (Instituto Nacional De Ciencias Neurologicas)	Dr. Guevara-Silva has nothing to disclose.
Mario R. Cornejo Olivas, MD (INSTITUTO NACIONAL DE CIENCIAS NEUROLOGICAS)	Dr. Cornejo Olivas has received research support from UNIVERSIDAD CIENTIFICA DEL SUR. The institution of Dr. Cornejo Olivas has received research support from CHDI. The institution of Dr. Cornejo Olivas has received research support from NIH. The institution of Dr. Cornejo Olivas has received research support from GP2/ASAP/MJFF. Dr. Cornejo Olivas has a non-compensated relationship as a Secretary elect with MDS-PAS that is relevant to AAN interests or activities.

��ɫ��

��ɫ��