Abstract Details

Title Clinical Profile of Frontotemporal Dementia: Case Series from a Neurological Care Center in Peru

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 7-006

Objective To determine clinical features of patients affected with frontotemporal dementia (FTD) followed up at a Neurological healthcare center in Peru.

Background FTD is a clinical syndrome. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. The prevalence of FTD in Peru is estimated at 1.9%. There is limited information on clinical aspects of FTD in the Peruvian population.

Design/Methods

We reviewed clinical records of patients diagnosed with probable FTD over 2010-2020 using 2011 diagnostic criteria. Local IRB approval was obtained for this study.

Results We included 21 cases that fulfilled the selection criteria. Twelve cases (57.1%) were categorized as bvFTD, 8 cases (38.1%) nfvPPA, and 1 (4.8%) svPPA. There was slightly male predominance (57%). The average of education was 9.6±4.6 years. The two main regions of origin were Lima (6 cases) and Ancash-northern Peru (6 cases). We found 6.67±3.73 and 4.75±2.19 years of diagnostic delay for bvFTD and PPA, respectively. The mean age at onset for bvFTD and nfvPPA groups was 50.7±9.7, and 62.4±12.26 respectively. The first symptom identified in the bvFTD group was disinhibition 6 (50%), while nfvPPA was effortful, halting speech 6 (75%). The most frequent supportive symptoms for bvFTD were disinhibition and apathy 8 (66.7%). Dysexecutive dysfunction was present in 11 (91.7%) and loss of empathy 1(8.3%). nfvPPA group showed agrammatism in language production and effortful speech in 7 patients (87.5%), parkinsonism was present in 5 patients (62.5%).

Conclusions The main clinical features of the FTD reported are consistent with existing literature. Loss of empathy is not identified as a supporting symptom of bvFTD. Further studies are required to identify associated factors affecting the timely diagnosis of FTD in Peru.

Authors/Disclosures
Sheila C. Suarez, MD (Instituto Nacional De Ciencias Neurologicas) PRESENTER	The institution of Dr. Suarez has received research support from Alzheimer's Association.
Erik A. Guevara-Silva, MD (Instituto Nacional De Ciencias Neurologicas)	Dr. Guevara-Silva has nothing to disclose.
Mario R. Cornejo Olivas, MD (INSTITUTO NACIONAL DE CIENCIAS NEUROLOGICAS)	The institution of Dr. Cornejo Olivas has received research support from CONCYTEC-PROCIENCIA PERU. Dr. Cornejo Olivas has a non-compensated relationship as a Board member at Rare Disorders Burou (CCI-MINSA) with Ministry of Health in Peru that is relevant to AAN interests or activities.

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