Abstract Details

Title Clinical and Demographic Characteristics Associated With Poor Posterior Circulation Stroke Outcomes: Greater Cincinnati/Northern Kentucky Stroke Study

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 13-009

Objective We aim to better understand what clinical and demographic characteristics are associated with poor clinical outcomes in posterior circulation strokes.

Background Posterior circulation strokes (PCS) make up 20% of all strokes, yet there is poor understanding of what factors contribute to poor clinical outcomes. We investigated clinical and demographic characteristics associated with poor clinical outcomes in PCS using a population-based biracial cohort.

Design/Methods Greater Cincinnati Northern Kentucky Stroke Study (GSNKSS) 2010 and 2015 data were utilized to identify 1842 patients who were >20 years old with MRI-proven PCS. Eligible patients were then stratified based on functional outcomes (modified Rankin Scale<3 vs >/= 3, with >= 3 considered poor) according to demographics, stroke risk factors, tPA treatment, stroke location, and stroke mechanism were summarized. A multivariable logistic model was then used to identify the predictors for poor functional outcomes.

Results Age, female gender, higher NIHSS, higher baseline mRS, hypertension, atrial fibrillation, diabetes mellitus, temporal, thalamic, cerebellar, and brainstem location, and small-vessel and cardioembolic mechanism were associated with poor clinical outcomes (p-value <0.01). After multivariable analysis, higher NIHSS, higher baseline mRS, hypertension, temporal, thalamic, cerebellar, and brainstem location, and cardioembolic mechanism remained associated with poor outcomes (p-value <0.01, OR 95% CI >1.00).

Conclusions Understanding these factors associated with poor prognosis after posterior circulation stroke will allow for better prognostication and family counseling.

Authors/Disclosures
Lina Chervak, MD (University of Cincinnati - Neurology) PRESENTER	Dr. Chervak has nothing to disclose.
Stacie L. Demel, DO (University of Cincinnati Medical Center)	Dr. Demel has nothing to disclose.
	No disclosure on file
Adam S. Jasne, MD (Yale)	Dr. Jasne has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis.
Daniel Woo, MD, FAAN (University at Buffalo)	The institution of Dr. Woo has received research support from NIH.
Sharyl R. Martini, MD, PhD (VHA Neurology)	Dr. Martini has nothing to disclose.
Tracy E Madsen	No disclosure on file
Eva A. Mistry, MD (UCCOM Neurology Stroke - 0525)	Dr. Mistry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for RAPID AI. Dr. Mistry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVIe. The institution of Dr. Mistry has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Silvercreek Pharma. Dr. Mistry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda Pharmaceuticals. Dr. Mistry has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for InspireMD. Dr. Mistry has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Shionogi. Dr. Mistry has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Mistry has received research support from National Institutes of Health. The institution of Dr. Mistry has received research support from Patient Centered Outcomes Research Institure.
Dawn O. Kleindorfer, MD, FAAN (University of Michigan Department of Neurology)	Dr. Kleindorfer has nothing to disclose.
Brett M. Kissela, MD, MS, FAAN (University of Cincinnati Hospital)	The institution of Dr. Kissela has received research support from NIH/NINDS. Dr. Kissela has a non-compensated relationship as a Board Member with AHA Regional Board that is relevant to AAN interests or activities.

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