好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Predictive Factors for Depressive Symptoms in the Stroke Recovery Follow-Up Period
Cerebrovascular Disease and Interventional Neurology
P7 - Poster Session 7 (8:00 AM-9:00 AM)
13-002

The purpose of this study is to investigate inpatient predictive factors for post-stroke depression (PSD) to better identify individuals who might derive the most benefit from targeted initiation of SSRIs.

Although SSRIs are no longer widely prescribed for post-stroke motor recovery, fluoxetine demonstrated beneficial effects on PSD. Given potential side effects of SSRIs, targeted initiation among individuals at highest risk for PSD warrants consideration. While previous studies have identified stroke severity and psychiatric history as factors associated with PSD, the predictability of PSD remains unknown.
All adult patients presenting to our tertiary academic stroke center with acute ischemic stroke between 2016-2020 were enrolled in a prospectively-collected stroke registry. Patients were seen 4-6 weeks post-discharge and a subset were administered the PHQ-9 (Patient Health Questionnaire-9) to screen for PSD (PHQ-9 ≥5). Demographics, history of depression, stroke severity, and inpatient PHQ-9 scores were abstracted. Logistic regression was used to determine factors associated with PSD and an ROC analysis determined the predictability of PSD in the inpatient setting.
307 individuals were administered the PHQ-9 at follow-up (mean age 65.5 years, 52% female). Individuals with history of depression (OR=4.22, 95% CI: 2.40-7.42), inpatient depression (OR=2.82, 95% CI: 1.80-4.43), higher stroke severity (OR=1.05, 95% CI: 1.01-1.10), and those living alone (OR=1.86, 95% CI: 1.01-3.40) had increased odds of PSD at follow-up. Marital status, employment, and outpatient therapy were not associated PSD. The ROC curve using a positive inpatient PHQ-9 achieved an area under the curve (AUC) of 0.62 (95% CI:0.57-0.67), while the AUC was 0.69 (0.64-0.74) after adding history of depression.
History of depression and a positive inpatient PHQ-9 appear to be most strongly associated with long-term PSD. Initiating SSRIs only in those individuals at higest risk for PSD may help reduce the burden of stroke recovery in this targeted population.
Authors/Disclosures
Julie S. Yi, MD (Johns Hopkins Hospital)
PRESENTER 		Ms. Yi has nothing to disclose.
No disclosure on file
No disclosure on file
Elisabeth B. Marsh, MD, FAAN (Johns Hopkins School of Medicine) Dr. Marsh has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for 好色先生. Dr. Marsh has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for American Neurological Association. Dr. Marsh has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Stroke. Dr. Marsh has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for ACTN. The institution of Dr. Marsh has received research support from American Heart Association. The institution of Dr. Marsh has received research support from National Institutes of Health. The institution of Dr. Marsh has received research support from National Institutes of Health.