Abstract Details

Title Prevalence and Risk Factors of Polyvascular Disease in Patients with Cerebrovascular or Ischemic Heart Diseases Undergoing Diagnostic Angiography

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P7 - Poster Session 7 (8:00 AM-9:00 AM)

Poster/Presentation
Number 13-007

Objective To assess the prevalence of polyvascular disease in patients with cerebral or myocardial ischemia; and to determine the different risk profiles, spectrum and clinical stages of comorbidities.

Background Polyvascular disease refers to patients with atherosclerotic lesions of two or more vascular beds, including cerebral, coronary, renal and peripheral arteries; with common conventional cardiovascular risk factors. Co-existing polyvascular disease is associated with revascularization priorities and complications.

Design/Methods We analyzed all the patients admitted to our hospital with cerebrovascular diseases or ischemic heart diseases underwent concomitant cerebral and coronary angiography between 2018 and 2021. Renal artery stenosis or proximal lower extremity peripheral artery disease (PAD) were also diagnosed by angiography. We classified symptomatic patients and preexisting risk factors based on medical history and blood tests. We used logistic regression analysis to estimate the associations between polyvascular comorbidities with risk factors by STATA 16.

Results We included 160 patients for analysis with the mean age of 63.2 and 76.9% males, of whom 93 (58.1%) had polyvascular disease; 50.0% presented with ischemic stroke or TIA within six months, 51.9% with acute coronary syndrome. Age (p=0.038), diabetes (p=0.007) and ever-smoker (p=0.047) are significant risk factors for polyvascular disease; while age (p=0.037) and diabetes (p=0.003) for ischemic symptoms. Compared with intra- or extra- cranial artery disease, PAD was more often a component of polyvascular disease (P = 0.003) and significant associated with ischemic symptoms. Carotid artery stenosis or occlusion showed significant association with coronary artery disease (p<0.001), while intracranial atherosclerotic stenosis only associated with PAD (p=0.031) among all comorbidities. Nineteen patients underwent concomitant percutaneous revascularization.

Conclusions The study revealed underestimated prevalence of polyvascular disease in East-Asian population, especially in patients with extracranial cerebrovascular diseases, of whom diabetes and age are major risk factors. Extracranial cerebral artery stenosis rather than intracranial atherosclerosis tended to be highly predictive of coronary artery disease.

Authors/Disclosures
Yi Shen, MD (Cedars-Sinai Medical Center) PRESENTER	Dr. Shen has nothing to disclose.
Jian Wu, PhD (Beijing Tsinghua Changgung Hospital)	Dr. Wu has nothing to disclose.
Xiaofeng Zhang (Beijing Tsinghua Changgung Hospital)	No disclosure on file

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