Abstract Details

Title Characteristics of Cerebral Cavernous Malformations in a Large Multiethnic Cohort

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P7 - Poster Session 7 (8:00 AM-9:00 AM)

Poster/Presentation
Number 13-009

Objective To understand the clinical features and natural history of cerebral cavernous malformations (CCM) in a large multiethnic population.

Background Many clinical and genetic characteristics of CCM are incompletely understood. Since most CCM studies are conducted in enriched populations such as Hispanic familial clusters, we lack comparable insights into CCM in other contexts and ethnicities, and how people with CCM compare with the general population. In this study, we describe a large multiethnic population with CCM.

Design/Methods This retrospective study included patients with CCM presenting to an academic medical centre in Virginia, USA between 1st January, 2010 and 23rd August, 2021. Demographic and clinical information were extracted from electronic medical records.

Results Of 425 eligible participants, 85.4% (363) were White, 7.8% (33) African American, 0.04% (4) Asian and 5.9% (25) identified as another racial or ethnic group. Only 1 person identified as multiracial. In contrast, the population of Virginia is 61.2% White, 19.9% African American, 6.9% Asian, 9.8% Hispanic/Latino and 3.2% multiracial. More than half of our cohort —59.1% (251)— was female. In comparison, Virginia's populaiton is 50.8% female. The mean age was 47 (standard deviation 18.20). Interestingly, people of Asian heritage were about two decades younger on average (mean age 29) than non-Asians with CCM (mean age 48 for White, 47 for African American, 39 for Other). Genetic status, radiographic features and other clinical aspects of CCM manifestation across these groups is revealing additional dimensions of the complexity of CCM.

Conclusions For the first time, we characterise a large multiethnic community with CCM. Our results demonstrate the unique sociodemographic features of this population and can further guide future clinical studies, classify cohorts for longitudinal studies and identify areas of unmet clinical need.

Authors/Disclosures
N. Abimbola Sunmonu, MD, PhD (Yale Neurology) PRESENTER	Dr. Sunmonu has nothing to disclose.
	No disclosure on file
Bradford B. Worrall, MD, MSc, FAAN (University Of Virginia Health System)	The institution of Dr. Worrall has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AAN. The institution of Dr. Worrall has received research support from NIH. The institution of Dr. Worrall has received research support from AHA/ASA.

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