Abstract Details

Title Assessing the Fatality Rate of Congenital Zika Syndrome Since the 2015 Zika Outbreak

Topic Child Neurology and Developmental Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 6-002

Objective We aimed to determine the perinatal case fatality rate in cases of Congenital Zika Syndrome (CZS) in a Brazilian Northeast State highly impacted by the Zika virus outbreak.

Background There is causal link between Zika virus (ZIKV) infection and microcephaly (MCP).

Design/Methods A cross-sectional study was conducted using data obtained through the State Health Department (SHD) for cases of MCP from April 2015 to December 31, 2017. Definition of perinatal period: commences at 22 completed weeks of gestation and ends seven completed days after birth. Perinatal case fatality rate is defined as the number of deaths as a fraction of the number of sick persons with a specific disease (×100).

Results There were 519 cases of MCP and others CA notified in RN, of which 150 were confirmed and 126 remain under investigation. The remaining 243 cases have been ruled out by presenting normal exams or due to presenting microcephaly by non-infectious causes. Of the total confirmed cases, 30.0% (45/150) died after birth or during pregnancy. 64.4% (29/45) of confirmed deaths had ZIKV infection during pregnancy and 4.4% (02/45) had a positive TORCH blood test. The deaths related to Zika were confirmed using either clinical/epidemiological/radiological (the presence of typical and indicative alterations of congenital ZIKV infection) or clinical/epidemiological/serological (RT-PCR and/or IgM/IgG antibodies against ZIKV). Eleven cases remain under investigation and five were ruled out.

Conclusions It highlights a high rate of perinatal lethality (64.4%) in cases of CZS. Despite the growing number of CZS cases, the real incidence and prevalence might be higher due to the underreporting and lack of resources for confirmatory diagnostic tests (laboratory and imaging). Because the severe neurological complications caused by CZS, it is likely to pose a substantial burden on public spending on healthcare. This study may be used to better describe the CZS, its prognosis and natural history.

Authors/Disclosures
Nilson Nogueira Mendes Neto, MD (Telemedicos) PRESENTER	Dr. Nogueira Mendes Neto has nothing to disclose.
	No disclosure on file
	No disclosure on file

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