Abstract Details

Title Quality of Life in People with Epilepsy: a Population-Based Study in the Detroit Metropolitan Area

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P17 - Poster Session 17 (11:45 AM-12:45 PM)

Poster/Presentation
Number 10-006

Objective Assess factors that influence quality of life in people with epilepsy in our patient population.

Background Certain socioeconomic, demographic and clinical variables are linked with worse quality of life (QoL) in people with epilepsy (PWE).

Design/Methods This cross-sectional study was conducted at the epilepsy outpatient clinic at Detroit Medical Center/Wayne State University as per institutional board review guidelines. Subjects (age > 18 years) with epilepsy were consented to participate in the study. Exclusion criteria included patients with cognitive disabilities and non-English speakers. Survey questions included patient demographics, seizure frequency, seizure type, number of anti-seizure medications (ASM), the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Patient Weighted Quality of Life in Epilepsy (QOLIE-10-P) scales. A score greater than 15 in the NDDI-E is suggestive of major depressive score and higher QOLIE-10-P scores are suggestive of poor QoL. A negative binomial regression analysis was done to determine associated factors.

Results A total of 520 surveys were collected, including follow-up patients, out of which 104 incomplete surveys were excluded from the analysis. From the 416 surveys included 60% female, 67% African American, and 23% in the 55+ age group. Females were associated with QOLIE-10-P scores at a rate 1.1 times greater than males (P = .04). Patients of ages older than 55 and patients with seizure frequency of ≥ 2 seizure/month had QOLIE-10-P scores 1.2 times greater than the age group 18-54 (P=.01) and seizure frequency of <2 seizure/month (P<.001), respectively. Every unit increase in the NDDI-E score was associated with an increase in QOLIE-10-P score by a factor of 1.1 (P<.001). There were no significant association between high QOLIE-10-P scores and race, number of ASM and seizure type (generalized tonic-clonic [GTC] vs. non-GTC).

Conclusions Older age, female gender, higher seizure frequency, and depression are associated with worse QoL in PWE.

Authors/Disclosures
Maryam J. Syed, MBBS (Wayne State University School of Medicine) PRESENTER	Dr. Syed has nothing to disclose.
	No disclosure on file
Rohit A. Marawar, MD, FAAN (Wayne State University - Detroit Medical Center)	Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz Pharmaceuticals. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SK Pharma. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Xenon. Dr. Marawar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis.
Maysaa M. Basha, MD, FAAN (Wayne State University, Detroit Medical Center)	Dr. Basha has nothing to disclose.
Deepti Zutshi, MD, FAAN (Wayne State University School of Medicine)	Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xenon pharmaceuticals. An immediate family member of Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aucta Pharmaceuticals. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aucta.

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