Abstract Details

Title Factors Associated with Depression in Epilepsy Patients: a Population-Based Study in the Detroit Metropolitan Area

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P17 - Poster Session 17 (11:45 AM-12:45 PM)

Poster/Presentation
Number 10-007

Objective The objective our study was to assess factors associated with incidence of depression in epilepsy patients.

Background Depression is a significant comorbidity of epilepsy, understanding the associated factors can help in screening depression in diverse patient populations.

Design/Methods

This cross-sectional study was conducted at the epilepsy outpatient clinic at Detroit Medical Center/Wayne State University as per institutional board review guidelines. Subjects (age > 18 years) with epilepsy were consented to participate in the study. Exclusion criteria included patients with cognitive disabilities and non-English speakers. Survey questions included patient demographics, seizure frequency, seizure type, number of anti-seizure medications (ASM), the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Patient Weighted Quality of Life in Epilepsy (QOLIE-10-P) scales. A score greater than 15 in the NDDI-E is suggestive of major depressive score and higher QOLIE-10-P scores are suggestive of poor QoL. A negative binomial regression analysis was done to determine associated factors.

Results A total of 520 surveys were collected, including follow-up patients, out of which 103 incomplete surveys were excluded from the analysis. the remaining 417 surveys included 58% females, 67% African American, and 23% in the 55+ age group. Seizure frequency of more than 2 [DZ1] ≤month (vs. < 2 seizures/month) were expected to have a rate 1.1 times greater for high [DZ2] er NDDI-E scores (P < .005). For every unit increase in QOLIE-10-P score, NDDI-E score increased by a factor of 1.1 (P < .001). Patient age, gender, race, number of ASM and seizure type were not significant contributors to depression.

Conclusions

Higher seizure frequency and poor quality of life are risk factors for depression in epilepsy patients.

Authors/Disclosures
Maryam J. Syed, MBBS (Wayne State University School of Medicine) PRESENTER	Dr. Syed has nothing to disclose.
	No disclosure on file
Rohit A. Marawar, MD, FAAN (Wayne State University - Detroit Medical Center)	Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz Pharmaceuticals. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SK Pharma. Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Xenon. Dr. Marawar has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis.
Maysaa M. Basha, MD, FAAN (Wayne State University, Detroit Medical Center)	Dr. Basha has nothing to disclose.
Deepti Zutshi, MD, FAAN (Wayne State University School of Medicine)	Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xenon pharmaceuticals. An immediate family member of Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aucta Pharmaceuticals. Dr. Zutshi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aucta.

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