Patients aged ≥ 18 years with primary diagnosis of Status epilepticus were identified from the Nationwide Inpatient Sample (NIS) from 2011 to 2014 using ICD-9 CM diagnosis code 345.2 and 345.3. Differences between categorical variables were tested using the chi-square test and continuous variables using the Student t-test. P values for trends were generated by Cochrane- Armitage test for categorical variables and simple linear regression for continuous variables.

We identified 76,370 patients with primary diagnosis of status epilepticus (Mean age 52 ± 19 years, 52.3% male, 56.4% white) during our study period, of which 346 (0.45%) had Petit mal and 76024 had grand mal seizures. Multivariate analysis for predictors of mortality showed increasing age per year (OR:1.04, 95% CI:1.03-1.05, p<0.001), Higher comorbidity index (OR:1.19, 95% CI:1.14-1.24, p<0.001), co-morbidities such as Diabetes mellitus (OR:1.51, 95% CI:1.21-1.88, p<0.001), Chronic Kidney disease (OR:2.24, 95% CI:1.73-2.89, p<0.001), Chronic liver disease (OR:1.98, 95% CI:1.34-2.91, p=0.001), Fluid and electrolyte disturbance (OR:2.03, 95% CI:1.67-2.47, p<0.001), admission in a teaching hospital (OR:1.85, 95% CI:1.49-2.28, p<0.001) were predictors of increased mortality. African American (OR:0.66, 95% CI:0.51-0.85, p=0.001) and Hispanics (OR:0.60, 95% CI:0.41-0.89, p=0.010) patient population as compared to Caucasian were associated with decreased mortality.