Abstract Details

Title Clinical Characteristics of 11 Cases with Visual Impairment After Herpes Virus Infection

Topic Infectious Disease

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 4-003

Objective

To investigate the clinical of visual impairment caused by herpes virus infection to provide reference for its diagnosis and treatment.

Background Viral encephalitis combined with visual impairment is rare clinically, with optic neuritis (ON) being the common cause in previous reports, followed by acute retinal necrosis syndrome (ARN).There is a natural link between ARN due to herpesvirus and herpesvirus neurological infection, which communicates with the anatomical structure usually the optic nerve.

Design/Methods The clinical manifestations, ancillary examinations, treatment and prognosis of patients with visual impairment after herpes viral infection, who admitted to Beijing Tongren Hospital from March 2013 to November 2020, were retrospectively collected and analyzed.

Results A total of 11 cases with visual impairment after herpesvirus infection were collected, one of which was female and the remaining 10 cases were male with a mean age of 50 years. Pathogenic examination revealed one case of herpes simplex virus (HSV), one case of pseudorabies virus (PRV), one case of Epstein-Barr Virus (EBV), and eight cases of herpes zoster virus (VZV). A total of 17 eyes were involved, including 5 cases of unilateral involvement and 6 cases of bilateral involvement. Causes of visual impairment: 6 cases of ON, 4 cases of ARN, and one case of optic perineuritis (OPN). 4 of the patients diagnosed with ARN were bilaterally involved and all had no light perception or only retained light perception.

Conclusions ON as well as ARN are common causes of viral encephalitis with visual impairment, and ARN is usually associated with more severe ocular damage and poorer treatment outcomes. Aggressive treatment is necessary for viral encephalitis, optic neuritis, acute retinal necrosis syndrome, or other comorbidities following herpesvirus infection, and early diagnosis and adequate antiviral therapy are key.

Authors/Disclosures
Jingxiao Zhang PRESENTER	Dr. Zhang has nothing to disclose.
Lei Liu, MD, PhD (Beijing Tongren Hospital,Capital Medical University)	Dr. Liu has nothing to disclose.

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