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Abstract Details

Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control
Movement Disorders
P2 - Poster Session 2 (11:45 AM-12:45 PM)
5-003
We report clinical outcomes associated with the use of DBS systems capable of directionality and Multiple Independent Current Control (MICC).
Deep Brain Stimulation (DBS) is an established treatment for motor signs and fluctuations associated with Parkinson's disease (PD). Retrospective studies can provide a relatively quick and cost-effective means to obtain data regarding various types of patient outcomes when devices are being used per standard-of-care in the real-world clinical setting, thereby contributing to real-world evidence (RWE). 
This is an international, multi-center observational study of DBS patient outcomes (NCT03664609) based on retrospective chart review. Patients assessed were implanted with a DBS system (Vercise, Boston Scientific) capable of MICC and/or directionality for use in the treatment of motor symptoms of Parkinson's disease. Data related to disease state, motor function, and overall quality of life are collected. Additionally, reduction in anti-parkinsonian medications usage is also assessed.

Data from 340 patients have been collected (mean age 65.5 ± 9.5 years, 69.5% male, disease duration of 12.9 ± 5.7 years). Of the patient data currently available (n = 104), 59% (n=61) reported a reduction in anti-parkinsonian medications at 12-months post-implant. A significant improvement in Quality of Life was noted at 12-months post-implant (6 pt. improvement in PDQ-39) supported by Global Impression of Change as assessed by clinicians (96% reported improvement). Cognitive health as measured by multiple relevant assessment scales (e.g. BDI, MOCA, MMSE) indicated stable mental status in most patients.

RWE obtained from this multicenter, observational case-series demonstrates improved quality of life, decreased medication intake and overall stable mental/cognitive status in Parkinson's disease patients at up to 12-months post-implant using a DBS system capable of directionality and Multiple Independent Current Control (MICC).
Authors/Disclosures
Theresa A. Zesiewicz, MD (University of South Florida)
PRESENTER 		Dr. Zesiewicz has received personal compensation for serving as an employee of Medscape. Dr. Zesiewicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lexeo. Dr. Zesiewicz has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Steminent. Dr. Zesiewicz has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Larimar. Dr. Zesiewicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Zesiewicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care.
Michael Barbe No disclosure on file
Steffen Paschen The institution of Steffen Paschen has received research support from Deutsche Forschungsgemeinschaft. The institution of Steffen Paschen has received research support from Parkinsonfonds. The institution of Steffen Paschen has received research support from UCB .
Corneliu C. Luca, MD (University of Miami) Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boston Scientific. Dr. Luca has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Signant Health. Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott.
Cong Zhi Zhao, MD (St. Luke'S Neurology) Dr. Zhao has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Efficient CME. Dr. Zhao has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Teva.
Francisco Ponce (Barrow Neurological Institute) No disclosure on file
Jennifer L. Durphy, MD (Albany Medical Center) Dr. Durphy has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Acorda.
Jill L. Ostrem, MD, FAAN (UCSF) Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz . Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Superness. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AcureX. Dr. Ostrem has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Larimar. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Aspen. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorders. The institution of Dr. Ostrem has received research support from Neuroderm. The institution of Dr. Ostrem has received research support from Boston Scientific. The institution of Dr. Ostrem has received research support from Medtronic. The institution of Dr. Ostrem has received research support from Rune.
No disclosure on file
No disclosure on file
Mustafa S. Siddiqui, MD, FAAN Dr. Siddiqui has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Boston Scientific Neuromodulation. Dr. Siddiqui has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. The institution of Dr. Siddiqui has received research support from Boston Scientific Neuromodulation. The institution of Dr. Siddiqui has received research support from Abbvie. The institution of Dr. Siddiqui has received research support from National Institute of Health .
Lilly Chen (Boston Scientific) Lilly Chen has received personal compensation for serving as an employee of Boston Scientific .
Roshini Jain Roshini Jain has received personal compensation for serving as an employee of Boston Scientific. Roshini Jain has received stock or an ownership interest from Boston Scientific.