Abstract Details

Title Cognitive performance and health-related quality of life in patients with neuromyelitis optica spectrum disorder

Topic Multiple Sclerosis

Presentation(s) P16 - Poster Session 16 (8:00 AM-9:00 AM)

Poster/Presentation
Number 12-006

Objective To describe the cognitive performance of a cohort of neuromyelitis optica spectrum disorder (NMOSD) patients, and assess the influence of demographic and clinical characteristics, and the relation with health-related quality of life (HRQoL) and other symptoms.

Background The frequency of cognitive impairment reported in NMOSD is highly variable, and its relationship with demographic and clinical characteristics is poorly understood.

Design/Methods A non-interventional, cross-sectional study was conducted in 13 Spanish centers. Demographic and clinical features were collected along with a cognitive z-score (Rao’s Battery), and patient-centered measures (29-item Multiple Sclerosis Impact Scale, Satisfaction with Life Scale, SymptoMScreen, 8-item Stigma Scale for Chronic Illness, Beck Depression Inventory (BDI-FS), Pain Effects Scale and Fatigue Impact Scale for Daily Use). The associations between cognition, demographic and clinical characteristics, and patient-centered questionnaires were explored with linear correlation analysis adjusted by age and gender. We used Akaike Information Criterion (AIC) to select the features that best fit the model.

Results Forty-one patients were studied (median age: 44 years, 85% female, median disease duration: 8.1 years). Fourteen (35%) patients had cognitive impairment (z-scores below -1.5 standard deviation in at least two tests), and the most affected cognitive domain was visual memory, followed by attention and information processing speed. Patients with cognitive impairment and those cognitively preserved were similar regarding age and gender (p>0.05). The final linear regression model included as variables associated with cognition: gender (β=-0.42, 95% confidence interval [CI]=-0.92,0.09, p=0.122), mood scores (BDI-FS, β=0.65, 95% CI=0.26,1.05, p= 0.012), fatigue (β=-0.39, 95% CI=-0.72,-0.05, p=0.036), satisfaction with life (β=0.34, 95% CI=0.08,0.6, p=0.031) and perception of stigma (β=-0.36, 95%CI=-0.64,-0.07, p=0.031); adjusted R2=0.396, p<0.001.

Conclusions These results highlight the association between cognition and emotional status in NMOSD patients. Cognitive and psychological assessments may be crucial to achieve a holistic approach in NMOSD patient care.

Authors/Disclosures
PRESENTER	No disclosure on file
Sara Llufriu	Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merci. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbot. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi.
Rocio Gomez	Rocio Gomez has received personal compensation for serving as an employee of Roche Farma.
Jorge Maurino	Jorge Maurino has received personal compensation for serving as an employee of Roche Pharma Spain, Medical Department.
Francisco Perez Miralles, MD	Dr. Perez Miralles has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Mylan. Dr. Perez Miralles has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Perez Miralles has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sanofi-Aventis. Dr. Perez Miralles has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen.
	No disclosure on file
Maria Sepúlveda	No disclosure on file
Carmen Calles, MD (Grupo 7 Viajes)	Dr. Calles has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi, Biogen, Roche, Teva, Novartis, Merck. Dr. Calles has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi, Teva, Biogen, Roche, Novartis, Merck.
Maria Luisa Martinez Gines, MD	Dr. Martinez Gines has nothing to disclose.
Ines Gonzalez	Ines Gonzalez has nothing to disclose.
Sabas Boyero	Sabas Boyero has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Sabas Boyero has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Sabas Boyero has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Sabas Boyero has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
	No disclosure on file
Angel P. Sempere, MD	Dr. Sempere has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Sempere has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Sempere has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Sempere has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Sempere has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Virginia Meca Lallana	Virginia Meca Lallana has nothing to disclose.
Luis Querol, MD, PhD (Hospital de la Santa Creu i Sant Pau)	Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CSL Behring. The institution of Dr. Querol has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for UCB. Dr. Querol has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ArgenX. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Dianthus. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Annexon. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avilar. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biocryst. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Immunovant. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for KPL. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lycia. The institution of Dr. Querol has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. Querol has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Querol has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Querol has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. The institution of Dr. Querol has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ArgenX. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Querol has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Grifols. The institution of Dr. Querol has received research support from GBS-CIDP Foundation International. The institution of Dr. Querol has received research support from Grifols. The institution of Dr. Querol has received research support from ISCIII. The institution of Dr. Querol has received research support from CIBERER. The institution of Dr. Querol has received research support from UCB. The institution of Dr. Querol has received research support from ArgenX.
Lucienne Costa C. Franca, Sr., PhD (Hospital Universitario Ramón y Cajal)	Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Almirall. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biopas. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristoll-Mayer. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Ipsen. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.
Albert Saiz (Hospital Clinico De Barcelona)	Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon Therapeutics. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janseen. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for novartis. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen.
Jose Meca Lallana, MD (Hospital Clinico Universitario Virgen De La Arrixaca)	Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sandoz. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol-Myers-Squibb. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Meca Lallana has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. The institution of Dr. Meca Lallana has received research support from Merck. The institution of Dr. Meca Lallana has received research support from Novartis. The institution of Dr. Meca Lallana has received research support from Roche. The institution of Dr. Meca Lallana has received research support from Sanofi. The institution of Dr. Meca Lallana has received research support from Biogen.
	No disclosure on file

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