To report on fertility characteristics, hormone response, and fertility treatment use among women with MS from different racial and ethnic backgrounds using NARCRMS database.

MS is a neurological autoimmune disease that commonly affects women more than men at a ratio of 3:1. Onset of MS typically occurs between the ages of 20-40, often affecting women during their childbearing years. Fertility and factors influencing it in women with MS have not been well understood or highly researched. Pregnancy has been an issue of concern for HCPs and MS patients due to the fears of the disease increasing obstetric risk, poor pregnancy outcomes, or potential increased risk of relapse after delivery.

This study utilizes the NARCRMS database which is a real-world registry of MS patients from 26 sites across the US, Puerto Rico, and Canada with different racial and ethnic backgrounds. Participants enrolled within the registry as of September 30^th, 2021 were included in this analysis. Data on demographics, fertility, hormone use, and pregnancies were captured for analysis. Limited data was included on DMT use during pregnancy across these populations.

At the time of the data capture there were 901 patients included in the database. Of these, 651 were females over the age of 18. A total of 443 pregnancies were reported on the registry with 320 (72%) of those being live births. Fertility treatments were used in 30 (6.7%) of these pregnancies. The racial and ethnic backgrounds examined in this analysis were: Caucasian whites: 84%, African Americans: 12%, Non-Hispanics: 77%, and Hispanics: 21%.

Our findings imply that most pregnancies in female MS patients from various racial and ethnic backgrounds have successful outcomes. A small percentage of patients used a fertility treatment. Further analyses are needed to understand fertility in both male and female MS patients.