Abstract Details

Title To compare the performance of various classification criteria in patients of idiopathic inflammatory myopathies in South Asian population.

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P16 - Poster Session 16 (8:00 AM-9:00 AM)

Poster/Presentation
Number 11-001

Objective To study the performance of various classification criteria of IIMs (idiopathic inflammatory myopathies) in patients who presented to tertiary care hospital in northern India.

Background IIMs are autoimmune/immune-mediated disorders of muscles with or without extra-muscular involvement. Advent of the new myositis-specific antibodies (MSA) has led to a better subclassification and prognostication of the disease.

Design/Methods Ambispective observational study at a single centre (retrospective: January 2014 to Dec 2019; prospective: Jan 2020- April 2021). All patients of IIMs with age > 14 years were recruited. Patients were classified according to the ACR/EULAR 2017, ENMC 119^th 2004 and Bohan and Peter criteria.

Results We classified our cohort of the patients according to the Bohan and Peter criteria, ENMC 119^th 2004 criteria and ACR/EULAR criteria. Of 76 patients, Bohan and Peter criteria classified 76.32% (n=58) as definite, 15.79% (n=12) as probable, 6.58% (n=5) possible inflammatory myositis and none- 1.32% (n=1). According to the ENMC 2004 criteria, out of 73 patients who had definite biopsy excluding the IBM patients 83.56% (n=61) were classified as DM, 12.32% (n=9) were classified into PM and three patients(n=3) into nonspecific myositis. ACR/EULAR criteria, 29 (35%) were dermatomyositis, 41(50%) were polymyositis / IMNM, 4 (5%) were JDM and 7(8.6%) were IBM patients. We compared the agreement of the criteria between Bohan and Peter and ACR/EULAR for the classification of the seventy-five patients with muscle biopsy to be having the inflammatory myopathy, the Cohens kappa was 0.435 suggestive of the moderate agreement.

Conclusions

ACR/ EULAR criteria still classified 50% of the patients to PM subgroup but ENMC 2004 classified 83% of patients to DM. Even with the histopathological characteristics of DM, absence of classical cutaneous manifestations at the time ofdiagnosis to subclassify according to the ACR / EULAR criteria, due to the difficulty in proving the heliotrope rash in thedark-skinned population.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Padma V. Hadakasira, MD (Medwis Healthcare Communications Pvt Ltd)	Dr. Hadakasira has nothing to disclose.
Rohit Bhatia, MD, MBBS, DM	Dr. Bhatia has nothing to disclose.
Mamta B. Singh, MD, MBBS, DM, FAAN (All India Institute of Medical Sciences)	Dr. Singh has nothing to disclose.
Roopa Rajan (Sree Chitra Tirunal Institute for Medical Sciences and Technology)	Roopa Rajan has received research support from DBT. Roopa Rajan has received research support from DST-SERB. The institution of Roopa Rajan has received research support from Michael J Fox Foundaton.
	No disclosure on file
Rajesh Kumar Singh	Rajesh Kumar Singh has nothing to disclose.
	No disclosure on file

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