Abstract Details

Title Guillain-Barré Syndrome after the ZIKV Epidemic in Colombia: A Multicenter, Prospective, Case-control Study

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 11-005

Objective To investigate risk factors associated with Guillain-Barré syndrome (GBS) in Colombia (South America).

Background During the outbreak of Zika virus (ZIKV) infection in Colombia in 2015-2016, there was an increase in the number of GBS cases. The Neuroviruses Emerging in the Americas Study (NEAS) network was established in 2016 as an multicenter-based study and observatory to investigate acute neuroimmunological disorders including GBS and the role of emerging pathogens.

Design/Methods A prospective case-control study was conducted between January 2016 and December 2020 at hospitals in 5 Colombian cities. Newly diagnosed patients with GBS, healthy household controls, and age and season-matched hospital controls with febrile illness were included. Clinical information, blood, CSF and urine biological samples were collected to determine recent infection by immunological and molecular assays.

Results

Fifty-seven patients with GBS, 66.7% male, with a median age (IQR) of 52 years (24-64) were recruited along with 53 household-controls and 19 hospital-controls. The association of GBS with male sex (OR, 2.24; 95% CI 1.44-3.47; p<0.01), preceding fever (OR, 16; 95% CI 2.12-120.6; p=0.007), headache (OR, 10; 95% CI 1.28-78.11; p=0.028), diarrhea (OR, 14; 95% CI 1.84-106; p=0.011), and history of recent upper respiratory tract infection (OR, 17; 95% CI 2.26-127 p=0.006) was observed when compared to household-controls. Odds ratio for recent infections did not significantly differ between cases and controls although recent exposure to C. jejuni (32.1%), M. pneumoniae (25%), Chikungunya virus (9.1%), flavivirus (3.6%) infection was observed.

Conclusions After the ZIKV epidemic, C. jejuni, M. pneumoniae and Chikungunya virus were the most common preceding infections in GBS in Colombia. Larger studies are necessary to determine the association between pathogens and GBS in our country.

Authors/Disclosures
Susana Dominguez Penuela, MD PRESENTER	Dr. Dominguez Penuela has nothing to disclose.
Martha Moyano	Martha Moyano has nothing to disclose.
Jose Enrique Vargas Manotas, MD, MSc (Private Office)	Dr. Vargas Manotas has nothing to disclose.
	No disclosure on file
Guillermo Gonzalez-Manrique	Guillermo Gonzalez-Manrique has nothing to disclose.
Jairo Francisco Lizarazo Nino, MD (Tecnofarma)	No disclosure on file
Jorge Angarita, MD	Dr. Angarita has nothing to disclose.
	No disclosure on file
Reydmar Lopez	Reydmar Lopez has nothing to disclose.
Daniela Zuluaga Lotero	No disclosure on file
David Acero-Garces, MD	Dr. Acero-Garces has nothing to disclose.
Maria A. Garcia-Dominguez, MD (UMass Memorial Medical Center)	Dr. Garcia-Dominguez has nothing to disclose.
Jose Enciso	No disclosure on file
Maria Fernanda Ramos Sanchez	No disclosure on file
Julie Benavides	Julie Benavides has nothing to disclose.
Katherine Claros	Katherine Claros has nothing to disclose.
Jaime Quintero	No disclosure on file
Jonathan Urrego	Jonathan Urrego has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Gustavo E. Ramos, MD (Universidad Libre De Cali, Universidad Del Valle, Clinica Dime)	Dr. Ramos has nothing to disclose.
	No disclosure on file
	No disclosure on file
Angela Catalina Vallejo Cajigas, MD (angela catalina vallejo cajigas)	Dr. Vallejo Cajigas has nothing to disclose.
Viviana Martinez	Viviana Martinez has nothing to disclose.
Carlos A. Pardo-Villamizar, MD (Johns Hopkins U, Med Dept of Neurology)	The institution of Dr. Pardo-Villamizar has received research support from National Institutes of Health. The institution of Dr. Pardo-Villamizar has received research support from Bart McLean Fund for Neuroimmunology Research .
Beatriz Parra	Beatriz Parra has nothing to disclose.
Lyda Osorio	Lyda Osorio has nothing to disclose.

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