The analysis included ten patients with IDH-1 wild-type (n=2) and mutant (n=1) glioblastomas, grade 1 meningioma (n=2), primary central nervous system lymphoma (n=1), hemangioblastoma (n=1), pilocytic astrocytoma (n=1), melanoma brain metastasis (n=1) and systemic metastases from colon cancer (n=1).  Median age was 77 (range 63-89) years.  Symptoms included constipation (n=8), bladder dysfunction (n=5), confusion or hallucination (n=5), REM sleep behavioral disorder (n=4), dementia (n=4), tremors (n=2), orthostasis (n=2) and anosmia (n=2).  Three individuals were L-dopa responsive.  Only one patient had a clinical diagnosis of Parkinson’s disease but he also had phospho-tau elevation in the cerebrospinal fluid indicating concurrent tauopathy.  Two had DaTscans; one showed a marked decrease of dopamine in both putamen and globus pallidus while the other had a more severe decrease of dopamine in the ipsilateral globus pallidus after treatment with radiosurgery.  There is a weak correlation between age and the number of symptoms (Pearson r²=0.4545).   Phosphorylated alpha-synuclein was found in 7 of 10 patients but no correlation was noted between the number of positive skin sites and symptoms (Pearson r²=0.1309).