This study aimed to compare the prevalence of developmental venous anomaly (DVA) in patients with different types of gliomas. This study also aimed to assess the association between DVA and two important mutations—IDH and MGMT.

A retrospective review analyzed consecutive intracranial tumor surgeries at the University of Washington between October 2013 and October 2015, of which all were WHO grade II-IV gliomas and patients from a study observing post radiation changes, of which all were WHO grade II-IV gliomas. Patients from a primary CNS lymphoma database were chosen consecutively as another comparison group. Chi-square test and multivariate analysis were used to determine the prevalence of DVA in 4 categories of gliomas and prevalence of DVA in gliomas vs. primary CNS lymphomas and to assess for association with mutation status of IDH and MGMT.

87 patients were enrolled in the study (male, n = 53; female = 34). We identified a higher prevalence of DVA in patients with oligodendroglioma (66.7%) compared to patients with anaplastic oligodendroglioma (27.2%), glioblastoma (16.2%), and anaplastic astrocytoma (6.7%). A chi-square analysis yielded a p-value of .00087, showing there is a statistically significant difference between these groups. As a whole, gliomas (20%) were found to have a higher incidence of DVA compared to primary CNS lymphomas (3%) with a p-value of .02.

A higher prevalence of DVA was found in patients with oligodendroglioma compared to other groups of gliomas.