Abstract Details

Title Pallidal Functional Connectivity Changes Are Associated with Disgust Recognition in Pure Motor Amyotrophic Lateral Sclerosis

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 008

Objective To investigate the resting-state functional connectivity (RS-FC) of the pallidum in ALS, and the relationship between RS-FC changes and disgust recognition.

Background In pure-motor ALS patients, we recently observed that smaller volume of the left pallidum was related with impaired recognition of disgust.

Design/Methods 19 pure-motor ALS patients and 52 matched healthy controls underwent RS functional MRI and a neuropsychological assessment including the Comprehensive Affect Testing System (CATS), investigating emotion recognition. A seed-based RS-FC analysis was run between the left and right pallidum and the rest of the brain, and compared between groups. Correlation analyses were assessed between the RS-FC significant changes and patients’ performance in recognizing disgust.

Results Compared to controls, ALS presented reduced RS-FC between bilateral pallidum and right superior and middle frontal gyri, and increased RS-FC between bilateral pallidum and left superior temporal and postcentral gyri, and left Rolandic operculum. Increased RS-FC was observed between left pallidum and left supramarginal gyrus and between right pallidum and contralateral insula and thalamus. In patients, lower performance in recognizing disgust was related with reduced RS-FC between bilateral pallidum and right middle and superior frontal gyri, and with increased RS-FC between bilateral pallidum and left postcentral gyrus and Rolandic operculum.

Conclusions In cognitively unimpaired ALS patients, reduced pallidum-frontal RS-FC and increased pallidum-insular-thalamic RS-FC suggest a fronto-striatal functional disconnection, which may contribute to deficits of patients in recognizing disgust.

Authors/Disclosures
Veronica Castelnovo, MSc (San Raffaele Scientific Institute, Vita-Salute San Raffaele University) PRESENTER	Dr. Castelnovo has nothing to disclose.
Elisa Canu (Ospedale San Raffaele)	The institution of Elisa Canu has received research support from Italian Ministry of Health .
	No disclosure on file
Elena Gatti	No disclosure on file
	No disclosure on file
	No disclosure on file
Vincenzo Silani, MD, FAAN (University of Milan Medical School - IRCCS Istituto Auxologico Italiano)	Dr. Silani has nothing to disclose.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Federica Agosta (San Raffaele Scientific Institute)	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.

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