Abstract Details

Title Cortical Remodeling Across the Lifespan in Healthy Brain Reveals Structural Network Vulnerability to Neurodegeneration

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 009

Objective To investigate cortical thinning changes across lifespan in healthy brain revealing structural network vulnerability to neurodegeneration.

Background Aging is the main risk factor for most of the neurodegenerative diseases. It is particularly challenging to understand the additive effect of aging into neurodegenerative disorders.

Design/Methods The cohort included 128 healthy individuals aged 20-85 years, who underwent an MRI scan. T1-weighted images were used to estimate vertex-wise cortical thickness maps, then grouped into 83 regions. For each region, cortical thickness trajectory with advancing age was estimated, including sex as covariate. Regions were ranked based on their relative thickness at the end of the observed lifetime, assessing regional changes over time. Mean regional thickness was correlated with relative change over time.

Results The highest cortical thinning was observed in the temporal lobe (parahippocampal, entorhinal, superior and middle temporal and fusiform), frontal lobe (lateral orbitofrontal, superior and inferior frontal, including pars triangularis and opercularis, and rostral anterior cingulate), parietal lobe (the isthmus of cingulate, precuneus, supramarginal and inferior parietal) and in the insular cortex. Interestingly, occipital regions (cuneus, lateral occipital, lingual, pericalcarine), and motor and premotor areas (precentral, postcentral and paracentral regions) showed the least cortical thickness change compared to the whole brain across lifespan. Finally, positive correlation was found between mean regional thickness and its relative change over time.

Conclusions This study highlights structural vulnerability of brain regions to aging and provides information concerning trajectories of normal brain aging, identifying those areas that might be more vulnerable to the attack of neurodegeneration.

Authors/Disclosures
Camilla Cividini, MSc (San Raffaele Scientific Institute, Vita-Salute San Raffaele University) PRESENTER	Ms. Cividini has nothing to disclose.
Federica Agosta (San Raffaele Scientific Institute)	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Silvia Basaia	Silvia Basaia has nothing to disclose.
Edoardo G. Spinelli, MD	Dr. Spinelli has nothing to disclose.
Veronica Castelnovo, MSc (San Raffaele Scientific Institute, Vita-Salute San Raffaele University)	Dr. Castelnovo has nothing to disclose.
Michela Leocadi, MSc (IRCCS San Raffaele Scientific Institute)	Dr. Leocadi has nothing to disclose.
	No disclosure on file
	No disclosure on file
Elisa Canu (Ospedale San Raffaele)	The institution of Elisa Canu has received research support from Italian Ministry of Health .
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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