Abstract Details

Title Functional Brain Connectome in Ventral and Dorsal Variants of Posterior Cortical Atrophy

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 010

Objective To investigate the functional brain connectome architecture in patients with ventral (vPCA) and dorsal (dPCA) variant of posterior cortical atrophy (PCA).

Background A diffuse pattern of functional network alterations in patients with PCA has been recently observed.

Design/Methods Thirty-six PCA patients, and 69 healthy controls were consecutively recruited at two specialized centers. All subjects underwent neurologic and cognitive examinations, and a brain MRI. Patients were categorized in vPCA (N=19) and dPCA (N=17) variants according to the prevalence of symptoms and were matched among each other for age, sex, education, MMSE and disease duration. Topological brain network properties and regional functional connectivity, using graph analysis and connectomics, were assessed and compared between groups.

Results Relative to controls, only vPCA patients showed global functional network alterations. The analysis of lobar network properties showed common alterations in terms of nodal strength within the occipital area in all PCA patients compared with controls; furthermore, compared to controls, vPCA showed additional involvement of the temporal, parietal and occipital areas. No differences were observed between PCA variants. At the regional level, compared to controls, each PCA variant showed diffuse functional connectivity breakdown. Compared to dPCA, vPCA patients showed further functional connectivity breakdown within the occipital and parietal lobe, and between frontal, sensorimotor nodes and basal ganglia.

Conclusions In a large PCA sample, our findings suggest the potentially high sensitivity of graph-analysis and connectomic in capturing signs of neurodegeneration in each variant of PCA. Although the two variants were matched for sociodemographic and clinical features, the vPCA group showed a more severe pattern of functional connectivity breakdown. Longitudinal investigations are needed to understand whether patterns associated with each PCA variant are able to predict distinct disease trajectories.

Authors/Disclosures
Camilla Cividini, MSc (San Raffaele Scientific Institute, Vita-Salute San Raffaele University) PRESENTER	Ms. Cividini has nothing to disclose.
Elisa Canu (Ospedale San Raffaele)	The institution of Elisa Canu has received research support from Italian Ministry of Health .
Federica Agosta (San Raffaele Scientific Institute)	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
	No disclosure on file
Silvia Basaia	Silvia Basaia has nothing to disclose.
Francesca Caso, MD (Universita' Vita Salute San Raffaele)	Dr. Caso has nothing to disclose.
Giuseppe Magnani	Giuseppe Magnani has nothing to disclose.
Maxime Montembeault, PhD (UCSF Memory and Aging Center)	Dr. Montembeault has nothing to disclose.
Richard Levy (La Pitie Salpetriere)	Richard Levy has nothing to disclose.
Raffaella Migliaccio (Hopital de la Pitie-Salpetriere)	Raffaella Migliaccio has nothing to disclose.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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