Abstract Details

Title The Association of Vasomotor Symptoms During the Menopausal Transition and Cognition in Later Life

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 017

Objective To determine if the burden of vasomotor symptoms (VMS) during the menopausal transition is related to later life cognition.

Background In the US, a majority of women experience VMS (night flashes and hot sweats) during the menopausal transition. VMS are associated with an increased risk of cardiovascular disease, and vascular disease is one possible pathway through which VMS impact cognition. Whether self-reported VMS are associated with cognition later in life remains unclear.

Design/Methods The Wisconsin Longitudinal Study is a prospective study of randomly selected Wisconsin high school graduates (class of 1957). At ages 65 and 72, a subset of participants completed six cognitive tests, including similarities, letter and category fluency, immediate and delayed word recall, and digit ordering. VMS score is a composite of response scores on the extent of hot flashes and night sweats. Nested regression models were used to examine the association between burden of VMS and baseline cognition at 65, adjusting for early-life socioeconomic status, women’s health variables (age of menarche and menopause, number of children, type of menopause, and HRT use), IQ, and income at 54. A series of models for cognition at age 72 additionally adjusted for cognition at 65. In sensitivity analysis models were repeated in a sample using multiple imputation for missing covariates.

Results Of the 5326 women enrolled, 874 had data on VMS, covariates, and all cognitive tests. In unadjusted models, higher VMS scores was associated with a lower similarities score (b= -0.09 95% CI -0.16, -0.02) at age 65 and lower letter fluency (b= -0.14 95% CI =0.27, -0.01) at age 72, but no other cognitive tests. In adjusted models, VMS were not related to cognition at age 65 or 72. Results remained similar with multiple imputation for covariates.

Conclusions Our study found no association between self-reported burden of VMS and measured later life cognition.

Authors/Disclosures
Amalia Peterson, MD (Columbia University) PRESENTER	Dr. Peterson has nothing to disclose.
Reena Gottesman, MD	Dr. Gottesman has nothing to disclose.
Eliza C. Miller, MD (University of Pittsburgh)	Dr. Miller has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for medical malpractice cases. The institution of Dr. Miller has received research support from National Institutes of Health. Dr. Miller has a non-compensated relationship as a member of ASA Advisory Council with American Heart Association/American Stroke Association that is relevant to AAN interests or activities.
	No disclosure on file

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