Abstract Details

Title Event-related potentials as biomarkers of cognitive performance in Alzheimer’s disease patients with cardiovascular risk factors

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 020

Objective

Our study examined how event-related potentials (ERPs) can help characterize neuropsychological performance among patients with AD dementia and cardiovascular risk factors.

Background

Electrophysiological measures are potential biomarkers of Alzheimer’s disease (AD) pathology. It is still unclear how these measures can be used to better identify cognitive deficits in AD patients with cardiovascular risk factors.

Design/Methods

Data were collected using a seven-electrode COGNISION™ rig in 185 older veterans from the VA Boston Healthcare System memory disorders clinic. EEG/ERP data were recorded while participants completed a three-tone auditory oddball task. All subjects were administered a neuropsychological battery composed of 8 subtests (e.g., CERAD memory task and Trails Making Test A and B). Through review of medical history, we selected a subset of patients (N=34) that met the following criteria: core clinical criteria for probable AD dementia, ≥ 65 years of age, MMSE score between 20 and 26, and presence of ≥ 2 cardiovascular risk factors among hypertension, type 2 diabetes or prediabetes, hypercholesterolemia, and BMI ≥ 25kg/m².

Results

Linear regressions were computed for ERPs that correlated with neuropsychological measures. N200 target latency is positively associated with Trails Making Test B time (p=0.035). N100 standard amplitude is positively associated with recognition scores (p<0.001) on the CERAD memory task. Slow Wave target amplitude is negatively associated with number of intrusions (p=0.029) on the CERAD memory task. P200 target latency is positively associated with recognition scores (p=0.039) on the CERAD memory task, and with Trails Making Test A time (p=0.018).

Conclusions

ERP measures such as N200, N100, Slow Wave, and P200 are useful markers of cognitive status - especially of memory, processing speed, and executive function - in patients with probable AD dementia and cardiovascular risk factors. Overall, these ERPs represent a clinical tool to help characterize the cognitive deficits in AD patients with cardiovascular risk factors.

Authors/Disclosures
Anna Marin (Boston University School of Medicine) PRESENTER	Mrs. Marin has nothing to disclose.
	No disclosure on file
Ana L. Vives-Rodriguez, MD (Yale School of Medicine)	Dr. Vives-Rodriguez has nothing to disclose.
Renée DeCaro (Boston University)	No disclosure on file
Andrew E. Budson, MD (VA Boston Healthcare System)	Dr. Budson has received personal compensation for serving as an employee of Boston Center for Memory. Dr. Budson has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Budson has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Budson has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Eli Lilly. The institution of Dr. Budson has received research support from Department of Veterans Affairs. The institution of Dr. Budson has received research support from NIH. The institution of Dr. Budson has received research support from Bristol Myers Squibb. The institution of Dr. Budson has received research support from VoxNeuro. The institution of Dr. Budson has received research support from Eisai. Dr. Budson has received publishing royalties from a publication relating to health care. Dr. Budson has received publishing royalties from a publication relating to health care. Dr. Budson has a non-compensated relationship as a Alzheimer's Advisory Panel with Commonwealth of Massachusetts that is relevant to AAN interests or activities.
Katherine Turk, MD (Boston VA)	The institution of Dr. Turk has received research support from Alzheimer's Association. The institution of Dr. Turk has received research support from US Department of Veterans Affairs.

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