Abstract Details

Title Takotsubo’s Cardiomyopathy As A Result Of Guillain-Barre Syndrome: A Case Report And Review Of The Literature

Topic Autoimmune Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 041

Objective N/A

Background Guillain-Barre syndrome (GBS) is a demyelinating disease found secondary to many triggers. Excess catecholamines are hypothesized to cause Takotsubo’s cardiomyopathy (TCM). TCM often overlaps with other clinical vignettes, hence is often misdiagnosed. We report a case and review the literature to draw conclusions that suggest novel clinical benchmarks in dysautonomic GBS patients.

Design/Methods N/A

Results

A 64-year old woman presented with slurred speech, and unsteadiness despite no previous illness. After brief examination and referral to our institution, she demonstrated characteristics of GBS. Her condition deteriorated after admission to total ophthalmoparesis, quadriplegia and required mechanical ventilation. TCM was diagnosed after initial analysis of non-ST segment myocardial infarction from observing: global hypokinesia, 40% ejection fraction despite normal coronary arteries, and new intracardiac thrombus. She received immunoglobulins and Warfarin and improved over time.

Conclusions Ultimately the pathology of GBS – in terms of: sympathetic overload and greater demyelination of the afferent limb – causing TCM is fully implicated but not the pathomechanism. A conclusion drawn from review of the literature is that day of onset of TCM relates to severity of decrease of LVEF. We assert that early recognition of the symptoms of TCM is vital in preventing poor clinical outcomes.

Authors/Disclosures
Arnav Mahajan PRESENTER	Mr. Mahajan has nothing to disclose.
Surasak Komonchan (Prasat Neurological Institute)	Surasak Komonchan has nothing to disclose.
	No disclosure on file
	No disclosure on file

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