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Abstract Details

Mind Over Matter - or is it? Role of Right Temporoparietal Junction in Functional Neurologic Disorders
Aging, Dementia, and Behavioral Neurology
P1 - Poster Session 1 (9:00 AM-5:00 PM)
071
To highlight the possible association between developing functional neurological disorders and structural changes of the right temporoparietal junction (TPJ), a key region implicated in multisensory integration and the sense of self-agency. 
Sense of agency (SoA) is the perception that an action is the consequence of one’s own intention, and this phenomenon is altered in patients with functional neurologic disorders who have co-existing abnormalities of the TPJ. The TPJ region integrates body-related multisensory information and has a confirmed role in SoA. We present two cases clinically diagnosed with functional neurological disorders and corresponding right TPJ abnormalities.  
Case Report

CASE 1: A 19-year-old woman with diagnosed psychogenic non epileptic spells, presented for evaluation of acute onset gait imbalance and abrupt movements. Observation of the movements revealed jerky movements of her right hemi-body, occurring with variable intensity and frequency. Her gait was consistent with astasia-abasia, and neurological examination was otherwise unremarkable. CSF studies were negative for any autoimmune or infectious etiologies. EEG was normal. Gadolinium enhanced magnetic resonance imaging (MRI) of the brain revealed a non-enhancing white matter lesion in the posterior parietal lobe on the right subcortical and temporoparietal region. 

  

CASE 2:   

A 51-year-old man with prior suicide attempt, major depressive disorder, and no prior history of seizures, presented after a motor vehicle accident. On examination, he was appropriately responsive and oriented; with on-going distractible, generalized nonrhythmic shaking which alternated sides with his eyes closed. History was notable for a prior traumatic head injury. Routine EEG was normal, and MRI brain revealed encephalomalacia and laminar necrosis of the right temporal lobe, involving the right temporoparietal junction.  

  

Recognition of possible structural aberrancy in patients with the clinical diagnosis of a functional neurological disorder can help with a better understanding of the neuropathology of this debilitating yet understudied disorder. 
Authors/Disclosures
Areeba Siddiqui, MD (Southwest Medical/Optum Care)
PRESENTER
Dr. Siddiqui has nothing to disclose.
Batool A. Hussain, MD, MBBS (UC Davis Neurology) Dr. Hussain has nothing to disclose.
Sanaz Attaripour, MD, FAAN (University of California, Irvine) Dr. Attaripour has nothing to disclose.