Abstract Details

Title Adrenal Abnormalities and Stroke

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 086

Objective We examined the association of adrenal abnormalities with ischemic stroke and intracerebral hemorrhage (ICH).

Background Adrenal lesions are increasingly recognized as a potential cause of hyperaldosteronism and hypercortisolism, with adverse metabolic effects potentially increasing the risk of cardiovascular events. We examined the association of adrenal abnormalities with ischemic stroke and intracerebral hemorrhage (ICH).

Design/Methods We performed a cross-sectional study using data from the Cornell Acute Stroke Academic Registry (CAESAR), which includes patients with ischemic stroke and ICH at our medical center since 2018. As controls, we included randomly selected patients hospitalized with traumatic brain injury (TBI). We included patients who had undergone an abdominal CT with and without contrast. Imaging reports were reviewed for any mentions of adrenal abnormalities by reviewers blinded to the study hypothesis. We calculated prevalence rates of adrenal abnormalities by group and used logistic regression models, adjusted for demographics and vascular risk factors, to evaluate the association of adrenal abnormalities with ischemic stroke and ICH, in reference to those control patients with TBI.

Results Among 75 IS patients, 75 ICH patients, and 75 TBI controls, adrenal abnormalities were found in 12% of the TBI patients, 13% of the ICH patients, and 15% of the IS patients (P = 0.89). In multiple logistic regression models, adrenal abnormalities were not associated with ischemic stroke (OR, 1.1; 95% CI, 0.4-3.0) or ICH (OR, 1.1; 95% CI, 0.4-2.9).

Conclusions In a single-center cohort of patients, we found that patients with ischemic stroke or ICH did not have a higher prevalence of adrenal abnormalities than control patients. However, our study may have lacked power to exclude clinically significant associations, and future studies may be warranted to further investigate the role of occult hypercortisolism and hyperaldosteronism in stroke risk.

Authors/Disclosures
Hamza Chaudhry PRESENTER	Dr. Chaudhry has nothing to disclose.
Tehniyat Baig, MD (NewYork Presbyterian / Weill Cornell Medical Center)	Ms. Baig has nothing to disclose.
Hooman Kamel, MD (Weill Cornell Medical College)	Dr. Kamel has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. Dr. Kamel has received personal compensation in the range of $50,000-$99,999 for serving as a Endpoint adjudication committee with Boehringer-Ingelheim.

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