Abstract Details

Title Investigating a New Risk Factor of Subarachnoid Hemorrhage: Opium Use Disorder

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 088

Objective

We evaluated the association between OUD and SAH with consideration of other risk factors and subgroups of SAH: aneurysmal (aSAH) and non-aneurysmal (naSAH).

Background Subarachnoid hemorrhage (SAH) is associated with many known risk factors, including hypertension (HTN) and tobacco smoking. There is a paucity of research about the possible association between opioid use disorder (OUD) and SAH.

Design/Methods

In this case-control study, 417 patients diagnosed with SAH and 405 controls without history of SAH or cardiovascular disease were compared. The case and control groups were compared with regard to demographics and risk factors including gender, age, OUD, HTN, smoking, diabetes mellitus, and hyperlipidemia. Univariate analyses were used to determine the crude association between SAH and individual risk factors. Binary (case vs control) and multinomial (SAH subgroups vs control) logistic regression were utilized to evaluate the adjusted odds ratio (OR) of each predictor.

Results Univariate analysis showed a significant association between SAH and OUD, HTN, smoking and age younger than 65 years (all p<0.001). Univariate subgroup analysis did not remain significant for smoking and age younger than 65 years in naSAH patients. After adjusting the predictors, a significant association was found for OUD (OR=6.72), HTN (OR=1.95), TS (OR=1.64) and age younger than 65 years (OR=2.23) between SAH patients and controls (all p<0.05). Multinomial logistic regression analysis showed that OUD was more closely associated with aSAH (OR=8.55, p<0.001) than naSAH (OR=3.74, p=0.002).

Conclusions

Our study showed that OUD is a strong risk factor for SA, and patients with OUD were 6.7 times more likely to have SAH. Although OUD is a risk factor for both SAH subgroups, the association is higher for aneurysmal SAH.

Authors/Disclosures
Alireza Zandifar, MD (The Children's Hospital of Philadelphia, Roberts Center for Pediatric Research) PRESENTER	Dr. Zandifar has nothing to disclose.
	No disclosure on file
Luis Octavio Tierradentro Garcia, MD (Children's Hospital of Philadelphia)	Dr. Tierradentro Garcia has nothing to disclose.
Jorge D. Kim, MD (The Children's Hospital of Philadelphia (CHOP))	Dr. Kim has nothing to disclose.
Arastoo Vossough, MD (University of Pennsylvania - Children'S Hospital of Philadelphia)	Dr. Vossough has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Syneos Health. Dr. Vossough has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for DeepSight. Dr. Vossough has received publishing royalties from a publication relating to health care.
	No disclosure on file

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