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Abstract Details

Factors Associated with Depression after Hemorrhagic Stroke
Cerebrovascular Disease and Interventional Neurology
P1 - Poster Session 1 (9:00 AM-5:00 PM)
123
To determine factors associated with depression after hemorrhagic stroke.
Depression may affect recovery and functional outcome after hemorrhagic stroke.
We prospectively identified patients with non-traumatic hemorrhagic stroke between January 2015 and February 2021 and telephonically performed the Neuro-QoL depression inventory at 3- and 12-months post-stroke. We examined the relationship between depression (T-score >50) and both history and illness severity. We also compared depression at 3-months and 12-months.
71 patients completed the 3-month call; 17 (24%) had depression. Patients with depression at 3-months were more likely to have history of depression (18% vs. 2%, p=0.014), SSRI use prior to admission (24% vs. 4%, p=0.01) and be unemployed (69% vs. 39%, p=0.047). On multivariate analysis of history of depression/SSRI use and employment, history of depression/SSRI use remained an independent predictor of depression 3-months post-stroke (p=0.018, OR 9 (95% CI 1.47-55.35)). 32 patients (45%) completed the 12-month call; 6 (23%) had depression. There was no agreement between depression at the two time points (κ=0.179); 22 patients (69%) did not have depression, 4 (13%) were only depressed at 3-months, 4 (13%) were only depressed at 12-months and 2 (6%) were depressed at both time points. Patients with depression at 12-months were more likely to have history of smoking (83% vs. 28%, p=0.022), premorbid mRS score >0 (67% vs. 15%, p=0.009), and higher APACHE II score at admission (median 16 (IQR 10.75-18.75) vs. 9 (IQR 6.75-12.5), p=0.043). On multivariate analysis, history of smoking and premorbid mRS score >0 remained significant predictors of depression 12-months post-stroke (p=0.032, OR 12.77 (95% CI 1.25-130.25) and p=0.016, OR 16.38 (95% CI 1.69-158.75), respectively)).
Presence of depression, and factors associated with depression, at 3-months and 12-months after hemorrhagic stroke differ. Further investigation is needed to tailor interventions to prevent and treat short- and long-term depression.
Authors/Disclosures
Janice Chou, MD
PRESENTER 		Dr. Chou has nothing to disclose.
No disclosure on file
Anlys Olivera, MD, PhD (NYU Langone Medical Center) Dr. Olivera has nothing to disclose.
Aaron Lord, MD (NYU Langone-Brooklyn) Dr. Lord has nothing to disclose.
Lindsey Gurin, MD (Langone Orthopedic Hospital) Dr. Gurin has received personal compensation in the range of $0-$499 for serving as a physician reviewer with Healthcare Quality Strategies, Inc. Dr. Gurin has received personal compensation in the range of $500-$4,999 for serving as a consultant with Human Services Research Institute.
Koto Ishida, MD, FAAN (NYU) Dr. Ishida has received publishing royalties from a publication relating to health care.
Kara R. Melmed, MD (NYU Langone Neurology Associates) Dr. Melmed has nothing to disclose.
Jose L. Torres, MD (NYU) Dr. Torres has nothing to disclose.
Barry M. Czeisler, MD, MS, MHPE, FAAN (Providence Specialty Medical Group) Dr. Czeisler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for NeuroStat Consulting LLC. Dr. Czeisler has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for NeuroStat Consulting LLC. Dr. Czeisler has stock in Brainspace. Dr. Czeisler has received publishing royalties from a publication relating to health care.
Cen Zhang, MD Dr. Zhang has nothing to disclose.
Jennifer A. Frontera, MD (NYU Langone Health) Dr. Frontera has received personal compensation in the range of $500-$4,999 for serving as a Consultant for FirstKindMedical. Dr. Frontera has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Physician 好色先生 Resource. The institution of Dr. Frontera has received research support from NIH. The institution of Dr. Frontera has received research support from Alexion. Dr. Frontera has received publishing royalties from a publication relating to health care.
Ariane Lewis, MD, FAAN (NYU Langone Medical Center) Dr. Lewis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Seminars in Neurology. Dr. Lewis has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Neuroscience.