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Abstract Details

Association of behavioral activation system with dopaminergic striatum in Parkinson’s disease patients
Movement Disorders
P1 - Poster Session 1 (9:00 AM-5:00 PM)
242
To compare association with striatal dopaminergic function between behavioral activation system (BAS) and behavioral inhibition system (BIS) in patients with Parkinson’s disease (PD).
Patients with PD present some neuropsychiatric symptoms such as dysfunction in the executive function and decision making. According to the Gray’s model, human behavior is controlled by the conflict between BIS and BAS. Executive function is shown to be commanded by dopaminergic front-striatal network which is affected in PD. However, association between dopaminergic striatal function and the BIS/BAS is unknown.
Drug naïve PD patients underwent clinical assessment of motor function (MDS-UPDRS part III) and BIS/BAS questionnaire, and 123I-Ioflupane SPECT. MDS-UPDRS part III was assessed as its total score and subscores of bradykinesia, rigidity and tremor in the right and left side separately. BAS was assessed as subscores of drive, reward responsiveness and fun seeking as well as its total score. Uptake of 123I-Ioflupane was assessed in each part of the striatum on both sides using DaTQUANT software. Spearman correlation coefficients among each assessment scores were compared.
28 participants (male 16, female 12) were included in this study. The Mean ± SD of age was 69.8±10.7 years. Hoehn and Yahr scale of participants were 1 in 4 persons, 2 in 14, 3 in 10. BAS, but not BIS, was correlated with MDS-UPDRS part III total score (r=-0.467, p=0.012). Especially BAS subscore of drive correlated with rigidity (r=-0.400, p=0.035) and bradykinesia (r=-0.382, p=0.045) in the right side. BAS, but not BIS, was correlated with uptake in left total striatum (r=0.398, p=0.040), anterior putamen (r=0.408, p=0.038) and posterior putamen (r=0.447, p=0.022). 
BAS is associated with dopaminergic left striatum.
Authors/Disclosures
Hidetomo Murakami
PRESENTER 		The institution of Dr. Murakami has received research support from Ministry of 好色先生, Culture, Sports, Science and Technology.
No disclosure on file
Tomotaka Shiraishi, MD (The Jikei University School of Medicine) Dr. Shiraishi has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file