好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Structural and Functional Cerebellar Alterations in Parkinson’s Disease with Postural Instability and Gait Disorders
Movement Disorders
P1 - Poster Session 1 (9:00 AM-5:00 PM)
246

To assess structural and functional cerebellar alterations in Parkinson’s disease patients with postural instability and gait disorders (PD-PIGD) and correlations between MRI and clinical data.
Brain structures other than basal ganglia are likely to be involved in the pathophysiological process of PD. The role of cerebellum in PD has been explored during hand motor-tasks, while few studies investigated its activity during gait-simulating tasks and dual-task situations.
Twenty-one PD-PIGD patients and 23 age/sex-matched healthy controls underwent clinical assessment, structural and functional MRI, including a motor-task (foot anti-phase movements) and a dual-task (foot anti-phase movements while counting backwards by threes). Regional grey matter cerebellar volumes were assessed automatically using an atlas propagation and label fusion strategy based on the freely available human cerebellum template and probabilistic atlas (SUIT).  FMRI and structural images were co-registered, and activation was extracted from each cerebellar region. Spearman’s correlation test was used for the correlation analysis.
PD-PIGD patients showed reduced volumes in cerebellar motor and non-motor areas relative to controls. During the fMRI motor-task, patients showed greater activation of cognitive cerebellar areas (lobule VI and crus I-II) relative to healthy subjects. During the fMRI dual-task, PD-PIGD showed increased activity of cognitive areas (crus II) and a reduced activity of motor areas (lobules I-IV). Structural alterations of cerebellum were correlated with the increased activity of cerebellar cognitive areas. The increased activity of crus I during the motor-task correlated with a better motor performance in PD-PIGD patients.
The increased activity of non-motor cerebellar areas might be a consequence of grey matter atrophy or an attempt to compensate the functional failure of cerebellar motor areas. Structural and functional MRI metrics focusing on cerebellum are useful to characterize brain correlates of motor and dual-task abilities in PD-PIGD patients.
Authors/Disclosures
Silvia Basaia
PRESENTER 		Silvia Basaia has nothing to disclose.
Elisabetta Sarasso Elisabetta Sarasso has nothing to disclose.
Andrea Gardoni No disclosure on file
M. Antonietta Volonte, MD Dr. Volonte has nothing to disclose.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Federica Agosta (San Raffaele Scientific Institute) Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.