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Abstract Details

Motor Cerebro-Cerebellar Networks Breakdown Among Different Subtypes of Parkinson’s Disease
Movement Disorders
P1 - Poster Session 1 (9:00 AM-5:00 PM)
247
The aim of this study was to investigate functional alterations within motor circuits of the cerebro-cerebellar system in Parkinson’s disease (PD)-tremor-dominant (TD) and PD-postural instability and gait disorder (PIGD) groups using stepwise functional connectivity (SFC) method.
PD patients are usually classified as TD and PIGD phenotypes, based on the predominant motor signs. Recent MRI studies demonstrated that different PD subgroups are characterized by diverse pathophysiology mechanisms and altered functional connectivity patterns.
32 PD-TD and 26 PD-PIGD patients performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). 60 age- and sex-matched controls were also enrolled. SFC analysis aims to characterize regions that connect to specific seed brain areas at different levels of link-step distances. The cerebellar seed-region was identified using motor task in 23 controls. For each of the SFC maps, two-sample t-test comparisons between groups were performed.
The performance of the fMRI-motor task was associated with activation of the lobule VI and vermis of the cerebellum. SFC analysis at one-link step distance showed, in both PD subtypes, a decreased connectivity between seed-region and thalamus and parietal lobe relative to controls; across intermediate link-steps, a reduced connectivity was observed with frontal, parietal and occipital lobes. Only PD-PIGD patients showed lower connectivity at intermediate link-step distances between the seed-cerebellar region and sensorimotor areas. Moreover, SFC pattern identified different localization of functional over-connectivity in frontal lobe in both PD groups: inferior frontal gyrus and insula in PD-PIGD, and in orbitofrontal gyrus in PD-TD.
These findings highlight subtype-specific PD changes in cerebellar functional connectivity, providing novel insights into the pathophysiological mechanism underlying different motor phenotypes.
Authors/Disclosures
Silvia Basaia
PRESENTER 		Silvia Basaia has nothing to disclose.
Federica Agosta (San Raffaele Scientific Institute) Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
No disclosure on file
Camilla Cividini, MSc (San Raffaele Scientific Institute, Vita-Salute San Raffaele University) Ms. Cividini has nothing to disclose.
Tanya Stojkovic Tanya Stojkovic has nothing to disclose.
Iva Stankovic (Neurology Clinic, Clinical Center of Serbia, University of Belgrade) Iva Stankovic has nothing to disclose.
No disclosure on file
Luigi Albano, MD (IRCCS San Raffaele and Vita-Salute San Raffaele University) Luigi Albano has nothing to disclose.
Elisabetta Sarasso Elisabetta Sarasso has nothing to disclose.
Andrea Gardoni No disclosure on file
Roberta Balestrino (Università San Raffaele) No disclosure on file
Vladana Markovic No disclosure on file
Elka Stefanova No disclosure on file
Vladimir S. Kostic, MD, PhD (Institute of Neurology CCS) Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche. An immediate family member of Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alkaloid. The institution of Dr. Kostic has received research support from Ministry of 好色先生, Science and Technological Development of Serbia.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.