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Abstract Details

Incidence of Parkinson Disease in North America
Movement Disorders
P1 - Poster Session 1 (9:00 AM-5:00 PM)
271

NA
Parkinson disease (PD) incidence estimates have varied, underscoring the need for a simultaneous PD burden estimate derived from multiple epidemiological data sources. 

We estimated the age-sex-standardized and age- sex- specific incidences of PD for the year 2012 using samples from five data sources/ epidemiology projects in North America: (1) Kaiser Permanente Northern California (KPNC), (2) the Honolulu-Asia Aging Study (HAAS), (3) the Rochester Epidemiology Project (REP) (4) the U.S. Medicare program, and (4) the Ontario Health Insurance Plan. Our primary estimations were for individuals ages 65 and older using all datasets; KPNC, Ontario, REP datasets were used to estimate PD incidence for ages 45-64.
Aged-standardized PD incidence estimates ranged from 108-212/100, 000 persons for age 65+, and from 18-24/100,000 persons for ages 45-64. The Ontario Health care and Medicare program datasets produced incidence rates that were 1.5-1.8 times higher than found in KPNC, the REP and the HAAS. PD incidence increased with age in the decades 65-74 years, 75-84 years in every study sample. Datasets which required clinical expert diagnosis and used the strictest diagnostic criteria (HAAS, KPNC and REP) reported a decline in PD incidence at ages 85+, whereas the administrative datasets (Ontario and Medicare) estimated that the incidence of PD diagnosis + anti-PD medication use continued to increase. There were geographical-, sex- and race- associated variations in PD incidence.

PD incidence, as measured across multiple datasets, is higher than previously reported.  PD incidence estimates derived from information contained in medical records or claims may be influenced by the application of different diagnostic criteria to those records. Such approaches may also expose differences in the detection and documentation of qualifying (parkinsonism) and disqualifying (e.g., comorbid dementia) clinical features. However, our PD incidence estimates may also reflect variations in underlying risk markers, differing exposures to risk or protective factors.

 
Authors/Disclosures
Connie C. Marras, MD (Toronto Western Hospital)
PRESENTER 		Dr. Marras has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine Biosciences. The institution of Dr. Marras has received research support from Theravance Inc. The institution of Dr. Marras has received research support from Centogene.
No disclosure on file
Caroline M. Tanner, MD, PhD, FAAN (University of California San Francisco, Weill Institute for Neurosciences) Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Evidera. Dr. Tanner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Neurocrine. Dr. Tanner has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals/Cavion. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bial . Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Supernus. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Genentech. The institution of Dr. Tanner has received research support from Gateway LLC. The institution of Dr. Tanner has received research support from Roche\Genentech. The institution of Dr. Tanner has received research support from Michael J Fox Foundation . The institution of Dr. Tanner has received research support from National Institute of Health . The institution of Dr. Tanner has received research support from Department of Defense. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving as a Faculty, CME presentation with Medscape /WebND.
Stephen K. Van Den Eeden, PhD (Kaiser Permanente) Dr. Van Den Eeden has received personal compensation for serving as an employee of Kaiser Permanente Northern California. The institution of Dr. Van Den Eeden has received research support from NIH. The institution of Dr. Van Den Eeden has received research support from Biogen. The institution of Dr. Van Den Eeden has received research support from MJFF. The institution of an immediate family member of Dr. Van Den Eeden has received research support from NIH.
Rodolfo Savica, MD, PhD, FAAN (Mayo Clinic) The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc.
Web Ross, MD (Pacific Health Research and 好色先生 Institute) The institution of Dr. Ross has received research support from Michael J Fox Foundation. The institution of Dr. Ross has received research support from NIH.
No disclosure on file
James Beck, PhD Dr. Beck has received personal compensation for serving as an employee of Parkinson's Foundation. The institution of Dr. Beck has received research support from NIH, MJFF.
Allison Wright Willis, MD (University of Pennsylvania) Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Pharmacoepidemiology and Drug Safety. Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Wright Willis has received research support from NIH. The institution of Dr. Wright Willis has received research support from NIA. The institution of Dr. Wright Willis has received research support from Biogen. The institution of Dr. Wright Willis has received research support from Parkinson Foundation. The institution of Dr. Wright Willis has received research support from Arcadia.