Abstract Details

Title Parkinson's Disease in patients with Essential Tremor: a prospective clinical and functional neuroimaging assessment

Topic Movement Disorders

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 276

Objective Relate the results of TRODAT-SPECT imaging in patients with ET with potential progress to ET-PD

Background Patients with essential tremor (ET) have 3.5 times greater risk of developing Parkinson's disease (PD) throughout their lives, also known as ET-PD. Single photon emission computed tomography with radiotracer imaging of dopamine transporters (TRODAT-SPECT) can help differentiate these two diseases.

Design/Methods Thirty-six patients with ET were evaluated by neurological examination, the Archimedes spiral, and the MDS-UPDRS III scale on two occasions, after a mean interval of three years. SPECT was performed in all patients after the first visit.

Results Overall, six patients (16.6%) progressed clinically to ET-PD. Patients with ET-PD were older and age of tremor onset was later. The ET-PD group scored higher on the MDS-UPDRS III scale, especially for the presence of bradykinesia. SPECT imaging was altered in 83.3% of the ET-PD patients compared to 33% of the ET patients (p=0.034). Changes on the SPECT with asymmetrical hypouptake suggested progress to ET-PD (p=0.025).

Conclusions

Advanced age at onset of tremor, presence of bradykinesia and asymmetrical alteration in SPECT may be related to progression to PD in patients with ET. Changes in neuroimaging suggest that SPECT-TRODAT can be used to predict progress to PD in selected patients.

Authors/Disclosures
PRESENTER	No disclosure on file
Carlos Henrique F. Camargo, MD, PhD, MSc, FAAN (Inovare Serviços de Saude Ltda.)	Dr. Camargo has nothing to disclose.
Giorgio Fabiani, MD (Dr. Giorgio Fabiani)	Dr. Fabiani has nothing to disclose.
	No disclosure on file
Rui Kleber Martins-Filho	No disclosure on file
Renato P. Munhoz, MD, PhD	Dr. Munhoz has nothing to disclose.
Helio Afonso G. Teive, MD, PhD, FAAN	Dr. Teive has nothing to disclose.

��ɫ��

��ɫ��