Abstract Details

Title The White Matter Rounds Experience: The Importance of a Multidisciplinary International Network to Accelerate the Diagnostic Process for Adult Patients with Rare White Matter Disorders

Topic Multiple Sclerosis

Presentation(s) P1 - Poster Session 1 (9:00 AM-5:00 PM)

Poster/Presentation
Number 314

Objective To present the experience of the White Matter (WM) Rounds Network and demonstrate the usefulness of collaborative multidisciplinary international case discussion meetings in improving the diagnostic rate in patients with rare white matter disorders.

Background Adult patients with genetic leukoencephalopathies or atypical white matter abnormalities often experience considerable delays before receiving a final diagnosis, due to the rarity of their conditions and the clinical and radiological overlap between hereditary and acquired white matter disorders, especially multiple sclerosis (MS). In this context, a strong collaborative network between same-field experts is beneficial for shortening the diagnostic odyssey of these patients and for preventing misdiagnosis. The WM Rounds is a multidisciplinary network of physicians and scientists from North America, Europe, and Middle East, that gather every month to discuss patients with atypical white matter disorders and that form a strong collaborative network.

Design/Methods We retrospectively reviewed the demographic, clinical and radiological data of all the subjects presented at the WM Rounds since its creation in 2013.

Results

Eighty-one patients (mean age 43.9) have been referred and discussed at the WM Rounds since 2013. In most cases, the referring physician was a geneticist (36/81; 44.4%) or an MS specialist (34/81; 41.9%). Thanks to the WM Rounds recommendations, a final diagnosis was made in 36/81 (44.4%) patients. Of these, 25 (69.4%) were diagnosed with a genetic neurological disease, six of whom (6/26, 23.1%) had been initially assessed in MS clinics.

Conclusions

The experience of the WM Rounds Network demonstrates the benefit of joining efforts through collective discussions on challenging patient cases to increase the diagnostic rate and prevent misdiagnosis. Networks of this nature allow physicians and scientists to compare and share information on rare cases from across the world and provide a basis for future multicenter research studies.

Authors/Disclosures
Yutong Huang (McGill University) PRESENTER	Miss Huang has nothing to disclose.
Paul S. Giacomini, MD (Montreal Neurological Institute)	Dr. Giacomini has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Innodem Neurosciences. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for F. Hoffmann- La Roche. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for F. Hoffmann-La Roche. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for F. Hoffman-La Roche. Dr. Giacomini has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Novartis. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for EMD Serono. Dr. Giacomini has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sanofi.
Rami Massie, MD (McGill University)	Dr. Massie has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Gowlingwlg. Dr. Massie has received personal compensation in the range of $500-$4,999 for serving as a Lecturer with Pfizer. Dr. Massie has received personal compensation in the range of $500-$4,999 for serving as a Advisory Board with Argenx.
Sunita Venkateswaran, MD (Children'S Hospital of Eastern Ontario)	Dr. Venkateswaran has nothing to disclose.
Roberta La Piana (McGill University)	Roberta La Piana has received research support from Canadian Institute Health Research. Roberta La Piana has received research support from Ataxia Canada. Roberta La Piana has received research support from Spastic Paraplegia Foundation. Roberta La Piana has received research support from Fonds de Recherche en Santé du Quebec. Roberta La Piana has received research support from Roche Canada. Roberta La Piana has received research support from ARSACS Foundation.
Anne-Marie Trudelle, MD	Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Trudelle has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme.
Giulia Fadda, MD (University of Ottawa)	Dr. Fadda has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen/Horizon Therapeutics. Dr. Fadda has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for roche. Dr. Fadda has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Fadda has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Novartis.
	No disclosure on file
Hayet Boudjani, MD	Dr. Boudjani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen . Dr. Boudjani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion.
Laurence Poliquin-Lasnier, MD	Dr. Poliquin-Lasnier has nothing to disclose.
Laura Airas, MD, PhD (Turku University Hospital)	Dr. Airas has nothing to disclose.
Alexander Saveriano, MD	Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi-Genzyme. Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD-Serono. Dr. Saveriano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pendopharm.
Myriam Levesque-Roy, MD (McGill University, Montreal Neurological Institute)	Dr. Levesque-Roy has nothing to disclose.
Matthias G. Ziller, MD	Dr. Ziller has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Erin Longbrake, MD, PhD, FAAN (Yale University)	Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Consultant for TG Therapeutics. Dr. Longbrake has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Longbrake has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Longbrake has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for ACTRIMS. Dr. Longbrake has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of Neurology. The institution of Dr. Longbrake has received research support from Genentech. The institution of Dr. Longbrake has received research support from NINDS K23. The institution of Dr. Longbrake has received research support from Robert Patterson Leet Trust. The institution of Dr. Longbrake has received research support from Biogen. The institution of Dr. Longbrake has received research support from National MS Society. The institution of Dr. Longbrake has received research support from Department of Defense. Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Study Section Member with Department of Defense (CDMRP). Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Programmatic Review with Department of Defense (CDMRP). Dr. Longbrake has received personal compensation in the range of $500-$4,999 for serving as a Study Section Member with National Institute of Health .
Jack P. Antel, MD, FAAN (Montreal Neurologic Hospital)	Dr. Antel has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for sanofi, roche, biogen, wave,nervgen. The institution of Dr. Antel has received research support from Novartis canada bristol myers squib. Dr. Antel has a non-compensated relationship as a past president with ACTRIMS that is relevant to AAN interests or activities.
Bernard Brais, MD (Montreal Neurological Institute-Hospital)	Dr. Brais has nothing to disclose.
Genevieve Bernard, MD (Research Institute of the McGill University Health Centre)	Dr. Bernard has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Calico. Dr. Bernard has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Orchard Therapeutics. Dr. Bernard has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for N/A. The institution of Dr. Bernard has received research support from Canadian Institutes of Health Research. The institution of Dr. Bernard has received research support from Montreal Children's Foundation. The institution of Dr. Bernard has received research support from Yaya Foundation for 4H Leukodystrophy. The institution of Dr. Bernard has received research support from Fondation Les Amis d'Elliot. The institution of Dr. Bernard has received research support from Ionis. Dr. Bernard has a non-compensated relationship as a Member of the Scientific Advisory Board with Pelizaeus-Merzbacher Foundation that is relevant to AAN interests or activities. Dr. Bernard has a non-compensated relationship as a Member of the Medical and Scientific Advisory Board with United Leukodystrophy Foundation that is relevant to AAN interests or activities. Dr. Bernard has a non-compensated relationship as a Chair of the Medical and Scientific Advisory Board with United Leukodystrophy Foundation that is relevant to AAN interests or activities. Dr. Bernard has a non-compensated relationship as a Member of the Scientific and Clinical advisory Council with Yaya Foundation that is relevant to AAN interests or activities.
Carolina A. Rush, MD	Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pendopharm . Dr. Rush has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi .
Roberta La Piana (McGill University)	Roberta La Piana has received research support from Canadian Institute Health Research. Roberta La Piana has received research support from Ataxia Canada. Roberta La Piana has received research support from Spastic Paraplegia Foundation. Roberta La Piana has received research support from Fonds de Recherche en Santé du Quebec. Roberta La Piana has received research support from Roche Canada. Roberta La Piana has received research support from ARSACS Foundation.

��ɫ��

��ɫ��