Abstract Details

Title Expanding frontiers in autoimmune encephalitis

Topic Autoimmune Neurology

Presentation(s) P2 - Poster Session 2 (9:00 AM-3:00 PM)

Poster/Presentation
Number 018

Objective To characterize a case series of Colombian patients with autoimmune encephalitis (AE).

Background

AE is often an under-recognized entity and antibody testing is not widely available in many developing countries. There is a lack of population-based data on AE in Colombia.

Design/Methods We made a comprehensive review of the literature on AE in Colombia. Additionally, we contacted researchers in other tertiary care institutions in Bogotá, Colombia to obtain information on additional unpublished cases.

Results 45 individuals were included and antibodies were identified in 73.3% of them. The most prevalent antibody was NMDA followed by LGI-1. Clinical characteristics according to the specific antibody were similar to those reported in the literature. Interestingly 1 patient had Zika virus (ZIKV) encephalitis 4 months before developing LGI-1 AE, and another patient developed an immunodeficiency following a NMDA related AE. A total of 5 patients had a negative antibody screen. There was no data on antibodies in 7 patients.

Conclusions

The clinical phenotypes of patients with AE in our case series were similar to those previously published. It is important to highlight a novel infectious trigger (ZIKV) and a postencephalitic immune mediated complication that, to the best of our knowledge, have not been previously reported in the literature. The initial diagnostic approach of AE can be based on clinical findings and conventional tests, especially in countries with limited resources where antibody testing is not accessible to all clinicians.

Authors/Disclosures
Habib Georges Moutran Barroso, MD (Universidad El Bosque) PRESENTER	Dr. Moutran Barroso has nothing to disclose.
Saul Reyes, MD (The Royal London Hospital)	Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for BIIB. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merck. Dr. Reyes has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Biogen.
Jaime E. Rodriguez, MD (Universidad El Bosque)	Dr. Rodriguez has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Jaime Toro, MD, FAAN (Universidad El Bosque)	Dr. Toro has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Watch Neurology .

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