Abstract Details

Title Severity of Symptoms Among Persons With Multiple Sclerosis by PDDS Score

Topic Multiple Sclerosis

Presentation(s) P13 - Poster Session 13 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-011

Objective To describe differences in MS symptom severity by PDDS score.

Background

The SymptoMScreen was developed to assess the severity of symptoms among persons with multiple sclerosis (pwMS). Patient Determined Disease Steps (PDDS), a self-reported measure of disability, was used as a criterion measure for the composite SymptoMScreen score. Although strongly associated, each individual SymptoMScreen domain can provide additional insight on the severity of MS symptoms. Evidence suggests that pwMS who report greater disability also experience increased severity across many symptoms (Gustaven 2021). It is necessary to understand symptom severity as MS progresses to identify ways to improve quality of life in pwMS.

Design/Methods The study sample included US participants who responded to the North American Research Committee on Multiple Sclerosis survey at least once in Fall 2017–Fall 2019 and completed the PDDS score and SymptoMScreen questions. When multiple surveys were available, the most recent information was used. Individual SymptoMScreen symptom domains, which utilize a seven-point Likert scale, were summarized overall and by PDDS score.

Results

The sample included 7646 pwMS across all PDDS scores (normal, 15%; mild, 14%; moderate, 9%; gait disability, 11%; early cane, 13%; late cane, 9%; bilateral support, 13%; wheelchair/scooter, 15%; bedridden, 1%). At normal, mild and moderate PDDS scores, the most frequently reported symptoms that were mild or more severe were fatigue (56%), cognition (37%) and bladder control (34%). At early cane or more severe PDDS scores, the most frequently reported symptoms that were moderate or more severe were bladder (73%), spasticity (64%) and fatigue (63%). All symptom domains increased in severity as PDDS score increased.

Conclusions All SymptoMScreen symptom domains increased in severity with higher disability levels; however, the most common symptoms differed at higher and lower PDDS scores. Interventions that can address MS symptoms can be insightful in selecting treatment.

Authors/Disclosures
Nicole G. Bonine, PhD (Genentech) PRESENTER	Mrs. Bonine has received personal compensation for serving as an employee of Genentech. Mrs. Bonine has stock in Genentech.
Caroline K. Geiger, PhD (Genentech Inc. - South San Francisco, CA)	Dr. Geiger has received personal compensation for serving as an employee of Genentech, Inc. Dr. Geiger has stock in Moderna. Dr. Geiger has stock in Abbott Laboratories. Dr. Geiger has stock in Gilead Sciences. Dr. Geiger has stock in Amgen. Dr. Geiger has stock in Roche. Dr. Geiger has received research support from National Science Foundation.
Vanessa Di Felice, MD, MPH (Genentech)	Dr. Di Felice has received personal compensation for serving as an employee of Genentech.
Amber Salter, PhD (UT Southwestern Medical Center)	Dr. Salter has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gryphon Bio. Dr. Salter has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abata Therapeutics. Dr. Salter has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sora Neuroscience. Dr. Salter has stock in Owl Therapeutics. The institution of Dr. Salter has received research support from National Multiple Sclerosis Society. The institution of Dr. Salter has received research support from Department of Defense Congressionally Directed Medical Research Program. The institution of Dr. Salter has received research support from Consortium of Multiple Sclerosis Centers.

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