A total of 267,558 patients with the diagnosis of MS were hospitalized during the study period, with a mean rate per 100,000 population of 7.7[+/- 0.2]. The rate per year of MS was fluctuating with the highest rate being in 2016 for 8.1/100,000. Patients were mostly female (73%) with a mean age of 44[+/-0.22] years old and mean length of stay of 4.5[+/-0.1] days.The mean charges in the cohort for each MS patient was $35,069 per admission, with a total cumulative aggregated charges of $ 1,102,282,270[+/- 35,869,591] during the cohort. The charges in teaching hospitals were higher $32,648, compared to non-teaching hospitals $28,300, respectively (p-Value=0 ). There has been a significant increase in charges from $ 27,231 in 2009 to $ 46,678 in 2019 (p-Value=0). When reviewing the charges in the Teaching as compared to the non-Teaching institutions, we observed a higher charge in the Teaching institutions during all years (p-Value=0). Using data from the Agency Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (HCUP) database, we examined all cases of MS from 2009 to 2019. Z-test statistic was used to compare the statistical significance in all 50 states of the United States.