Abstract Details

Title Idiosyncrasy in a Spanish-speaking developing country and Employment: study of general population and Multiple Sclerosis

Topic Multiple Sclerosis

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-005

Objective

Assess differences in the association of cognitive and clinical variables with work status between people with multiple sclerosis (PwMS) and healthy controls (HCs) and study the association between work-related difficulties - negative work events (NWE) and work hours per week - and work status in PwMS and HCs through the BVMS.

Background

PwMS are vulnerable to diverse unfavorable work experiences, from reduced hours to unemployment.

Design/Methods

We enrolled 80 PwMS & 80 HCs for a single examination that included Symbol Digit Modalities Test (SDMT), California Verbal Learning Test (CVLT), Brief Visuospatial Memory Test-Revised (BVMTR), & Dysexecutive Questionnaire (DEX). We used the Buffalo Vocational Monitoring Survey (BVMS) to investigate work status and work-related difficulties. Work status was classified into: Stable, Challenged or Loss. Work-related difficulties includes absenteeism, income, hours worked per week, and NWEs (verbal reprimands, demotions, etc.). Exploratory factor analyses (EFA) and Pearson correlations were performed.

Results

PwMS and HCs were matched on demographics. PwMS (EDSS: 3.18±2.44; disease duration: 13.23±9.14), were impaired on SDMT: 45.16±14.56, CVLT: 48.71±12.71, BVMTR: 21.30±12.65, and DEX: 21.36±12.04. Work status (PwMS vs. HCs): Stable: 51.2% vs. 90%, Challenged: 25% vs. 6.2%, & Loss: 23.8% vs. 3.8%.

PwMS: EFA (KMO 0.664, Bartlett 0.000), work status (0.779), SDMT (0.841), CVLT (0.821), and BVMTR (0.560) (α=.590) loaded into the 1° factor, and work status (0.021), DEX (0.891) and depression (0.897) (α=.765) into the 2° factor. HCs: EFA (KMO 0.572, Bartlett 0.000) work status (0.182), SDMT (0.790), CVLT (0.678) and BVMTR (0.751) (α .593) loaded into the 1° factor, and work status (-0.431), DEX (0.808) and depression (0.856) (α=.459) into the 2° factor.

In both groups, work status was associated with NWEs (PwMS: r=.864; p=.000, HCs: r=-.758; p=.000) and work hours per week (PwMS: r=.778;p=.000, HCs: r=.393; p=.000).

Conclusions

Processing speed and memory are associated with worse work status in PwMS, and depression and impaired executive functioning in HCs.

Authors/Disclosures
Sandra Vanotti PRESENTER	Sandra Vanotti has nothing to disclose.
Maria Sol Román	Maria Sol Román has nothing to disclose.
Lara Bardoneschi	Lara Bardoneschi has nothing to disclose.
	No disclosure on file
	No disclosure on file
Florencia Daniele	Florencia Daniele has nothing to disclose.
Maria Laura Saladino	Maria Laura Saladino has nothing to disclose.
Ralph H. Benedict, PhD (University At Buffalo)	Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Meyers Squibb. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunic Therapeutics. Dr. Benedict has received intellectual property interests from a discovery or technology relating to health care.
Fernando J. Caceres, MD	No disclosure on file

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