Abstract Details

Title Use of individual measure and Z-scores to monitor disease course in Relapsing Multiple Sclerosis: A 1-year Prospective Study in a Single Center

Topic Multiple Sclerosis

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-012

Objective To assess the performance of individual serum neurofilament (sNFL) values vs. Z-score to monitor inflammation in persons with relapsing forms of MS (pwRMS)

Background Population-based standards of sNFL levels have been recently proposed to detect activity in pwRMS. However, sNFL levels are variable, and the exact algorithm to diagnose individual-based disease activity is not defined yet.

Design/Methods A prospective cohort of 114 pwRMS were followed for 1 year. Clinical examination and sNFL assessment were performed and registered every three months. MRIs were performed annually. Baseline sNFL was the sNFL level measured at study inclusion in the absence of disease activity. Reference sNFL level was the lowest individual sNFL measure obtained during follow-up in the absence of disease activity. BMI-adjusted Z-score was registered for baseline, reference, and activity points. Non-parametric tests were used because data did not follow a normal distribution.

Results Median baseline sNFL levels were 6.85 (5.15 – 9.09); Z score 0.64 (-0.33 – 1.49). Median reference sNFL levels were 4.71 (4 – 5.87); Z score -0.36 (-1.13 – 0.42). Twenty-four patients (21.1%) had disease activity during follow-up. Median sNFL in these patients was 8.67 pg/ml (6.91 – 13) with an increase of 14.7% over the baseline level: 1.01 (-0.71 – 2.67; P = 0.66) and of 77% over the reference level: 3.63 (2.09 – 6.25; P = 0.001). Z-score during disease activity was 1.13 (0.45 – 2.27), overlapping with control levels in the population-based normogram. In our cohort, none of the individual sNFL measures or baseline Z-score predicted disease activity during the first year of follow-up, but patients with relapse at inclusion were more prone to have disease activity.

Conclusions

Establishment of an individual sNFL reference value in the first year of follow-up might help to better diagnose ongoing inflammation. Baseline sNFL was not as good comparator for this outcome.

Authors/Disclosures
Luis Rafael Solís-Tarazona, MD PRESENTER	Mr. Solís-Tarazona has received personal compensation for serving as an employee of Novo Nordisk A/S.
	No disclosure on file
	No disclosure on file

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