Abstract Details

Title A randomized, controlled trial of low-fat diet for fatigue in multiple sclerosis

Topic Multiple Sclerosis

Presentation(s) P6 - Poster Session 6 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-008

Objective Determine if a low-fat diet is effective at ameliorating fatigue in people with multiple sclerosis (PwMS) through a randomized controlled trial (RCT). Primary outcome is reduction in fatigue assessed via Modified Fatigue Impact Scale (MFIS) at 16 weeks.

Background Fatigue is a common, disabling symptom of multiple sclerosis (MS). A dietary intervention to improve fatigue is desirable given the minimal risk of adverse events.

Design/Methods PwMS were assigned to a low-fat diet (active) or wait-list (control) group. The active group received 4 weeks of data collection/nutrition counseling followed by adherence to the diet for 12 weeks. We measured diet adherence using monthly Food Frequency Questionnaire and 24-hr food recall. The principal statistical analysis used linear mixed models, with a random effect for subject to account for the within-subject correlation, in an intent-to-treat (ITT) framework to determine the effect of diet on the outcomes of MFIS and Fatigue Severity Scale (FSS). Sensitivity analysis was conducted by excluding potential outliers in both groups.

Results 39 participants were recruited with 20 in the active group and 19 in the control group. At baseline, participants' mean age was 50 years (±12 years), mean BMI was 31 kg/m² (±7 kg/m²), and mean EDSS was 3.8 (±1.4). Mean MFIS decreased by -4.00 (95% CI: -12.04, 4.04) and mean FSS decreased by -0.41 (95% CI: -1.18, 0.36) from baseline to the end of the RCT in active group compared to control. Sensitivity analysis strengthened the magnitude of association with a mean MFIS decrease of -13.93 (95% CI: -20.65, -7.20) and mean FSS decrease of -1.22 (95% CI: -1.94, -0.50) in active group compared to control. Percent calories from fat decreased by 10.56% (95% CI: -18.50%, -2.97%) in active group compared to control.

Conclusions This 16-week long low-fat dietary intervention reduced the fatigue score significantly in the active group compared to controls.

Authors/Disclosures
Vicky Chen, MD PRESENTER	Dr. Chen has received research support from OHSU Foundation.
	No disclosure on file
Michael A. Lane, MD (OHSU)	Dr. Lane has nothing to disclose.
Lindsey B. Wooliscroft, MD (Oregon Health & Science University)	The institution of Dr. Wooliscroft has received research support from National Institutes of Health.
	No disclosure on file
	No disclosure on file
Elizabeth Silbermann, MD (Oregon Health & Science University)	Dr. Silbermann has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. Dr. Silbermann has received research support from VA.
Jessica Rice, MD (Providence)	Dr. Rice has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Greenwich Pharmaceuticals.
Chris Hollen, MD (OREGON HEALTH & SCIENCE UNIVERSITY)	Dr. Hollen has nothing to disclose.
Allison Fryman	Allison Fryman has nothing to disclose.
Kayla Martin, MD (Colorado Permanente Medical Group)	Dr. Martin has received research support from Tartar Trust. The institution of Dr. Martin has received research support from OHSU Foundation.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Vijayshree Yadav, MD, FAAN (OHSU)	Dr. Yadav has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for American Association for Cancer Research Inc. Dr. Yadav has received personal compensation in the range of $0-$499 for serving as a Consultant for Kyverna. Dr. Yadav has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for University of Alabama. The institution of Dr. Yadav has received research support from Department of Veterans Affairs. The institution of Dr. Yadav has received research support from NIH. The institution of Dr. Yadav has received research support from Ad Scientiam. The institution of Dr. Yadav has received research support from HELIUS Medical Technologies/NeuroHabilitation Inc. Dr. Yadav has received research support from Anne Middleton Foster Endowed Professor for MS Research. The institution of Dr. Yadav has received research support from Tykeson Family Foundation Endowed Professorship. The institution of Dr. Yadav has received research support from NMSS.

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