52 patients with ischemic stroke divided into 3 groups. The I group stroke in the left middle cerebral artery, II–right middle cerebral artery, III- vertebrobasilary basin. Subpopulations of CD3+, CD4+, CD8+, CD16+, CD19+, as well as Interleukin-1β, Interleukin-4, Interleukin-8, Tumor necrosis factor-α were detected in venous blood serum. The functional state of the autonomic nervous system was assessed by R.M. Baevsky's method of mathematical analysis of heart rate variability. The observation period is 1 and 10 days from the onset of stroke.